Special Issue "Material Properties Underpinning Nanotoxicity Studies and Safety by Design Strategies"

A special issue of Nanomaterials (ISSN 2079-4991).

Deadline for manuscript submissions: closed (28 February 2018) | Viewed by 6794

Special Issue Editors

Prof. Dr. Iseult Lynch
grade E-Mail Website
Guest Editor
School of Geography, Earth and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Interests: nanomaterial synthesis and characterisation; nanoparticle-biomolecule interactions (eco-corona); fate and behaviour of nanomaterials; green/benign-by-design nanomaterials; nanosafety assessment; nanosafety data management
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Eugenia Valsami-Jones
E-Mail Website
Guest Editor
University of Birmingham, Birmingham, UK
Interests: nanomaterial properties; reactivity; toxicity; solubility; bio-nano interactions
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The concept of Safety by Design (SbD) was established to help the development of nanoparticles and materials with risk minimisation at every stage of the design process to achieve long term commercial potential and consumer confidence. Similarly, concepts around green nanomaterials and Benign by design (BbD) reflect the need the need to reduce reliance on critical non-renewable resources and to move away from the single-use culture towards a more circular economy. Together these concepts will help nanosafety and Environmental Health and Safety (EHS) consideration to keep up with innovation, and indeed merge into so-called “safe innovation”.

At the heart of SbD/BbD lies the concept of substituting the question “Is it safe/sustainable?” with “Can we engineer it to be safe/sustainable?” This Special Issue of Nanomaterials will attempt to cover the recent advances in the design of safe (lower hazard, exposure or persistence) and/or benign (green, recyclable, re-usable, lower impacts across the whole life cycle) nanomaterials, focussing on those molecular and physico-chemical properties (intrinsic and extrinsic to the material) driving hazard or exposure (and thus risk) and on strategies to design-out, replace, substitute or mitigate the undesirable effects whilst retaining functionality and cost-efficiency.

Prof. Dr. Iseult Lynch
Prof. Dr. Eugenia (Éva) Valsami-Jones
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • nanomaterials    
  • nanocomposites  
  • nano-hybrids    
  • nanosafety    
  • hazard assessment    
  • risk assessment    
  • classification    
  • grouping    
  • safe-by-design    
  • benign-by-design    
  • predictive toxicology

Published Papers (1 paper)

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Characterization of Nanoparticle Batch-To-Batch Variability
Nanomaterials 2018, 8(5), 311; https://doi.org/10.3390/nano8050311 - 08 May 2018
Cited by 48 | Viewed by 6394
A central challenge for the safe design of nanomaterials (NMs) is the inherent variability of NM properties, both as produced and as they interact with and evolve in, their surroundings. This has led to uncertainty in the literature regarding whether the biological and [...] Read more.
A central challenge for the safe design of nanomaterials (NMs) is the inherent variability of NM properties, both as produced and as they interact with and evolve in, their surroundings. This has led to uncertainty in the literature regarding whether the biological and toxicological effects reported for NMs are related to specific NM properties themselves, or rather to the presence of impurities or physical effects such as agglomeration of particles. Thus, there is a strong need for systematic evaluation of the synthesis and processing parameters that lead to potential variability of different NM batches and the reproducible production of commonly utilized NMs. The work described here represents over three years of effort across 14 European laboratories to assess the reproducibility of nanoparticle properties produced by the same and modified synthesis routes for four of the OECD priority NMs (silica dioxide, zinc oxide, cerium dioxide and titanium dioxide) as well as amine-modified polystyrene NMs, which are frequently employed as positive controls for nanotoxicity studies. For 46 different batches of the selected NMs, all physicochemical descriptors as prioritized by the OECD have been fully characterized. The study represents the most complete assessment of NMs batch-to-batch variability performed to date and provides numerous important insights into the potential sources of variability of NMs and how these might be reduced. Full article
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