Special Issue "Nanoparticles in Vivo and in Vitro Studies: A Collection of Parallel Approaches"
A special issue of Nanomaterials (ISSN 2079-4991).
Deadline for manuscript submissions: closed (31 October 2017).
Interests: effects of (nano)particle and fibers on the lung; general particle toxicity on human and animal tissue; in vitro studies on cells to predict particle effects; macrophage biology
Within the last decade, thousands of scientific publications have investigated the biologic activity of nanoparticles using mammalian cell models and rodents for risk estimation. However, studies in which in vitro and in vivo experiments make use of essentially the same nanoparticles have been undertaken far less frequently, although a maximal degree of similarity between in vitro and in vivo approaches appears mandatory for a sound validation of in vitro results.
In this sense, the in vivo findings based on biokinetic behaviour of nanoparticles and on toxicological results should set out the frame for the design of predictive cell tests: Starting with the selection of most appropriate and representative test cells, meaningful cellular doses of nanoparticles appear most important, along with a fine-tuned experimental setting meant to unravel and understand the sophisticated response of cells upon nanoparticle treatment.
This Special Issue of Nanomaterials is therefore devoted to original contributions in which in vitro work is reasoned and accompanied by in vivo studies with the aim to maximize the degree of similarity of both approaches. Well-motivated studies aiming at the risk estimation for animals and humans are welcome and acceptance will not depend on the degree of success, as long as contributions are in accord with 3R principles.
Prof. Dr. Martin Wiemann
Manuscript Submission Information
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- in vivo–in vitro comparison
- intratracheal instillation
- 3R principle
- validation study