Special Issue "Synthesis and Functionalization of Colloidal Nanoparticles"

A special issue of Nanomaterials (ISSN 2079-4991).

Deadline for manuscript submissions: 20 December 2020.

Special Issue Editors

Dr. Elisabetta Fanizza
Guest Editor
Dipartimento di Chimica, Università degli Studi di Bari Aldo Moro, Via Orabona 4, 70125 Bari, Italy
Interests: inorganic nanoparticles synthesis; nanoparticle size and shape regulation; luminescent semiconductors; plasmonic nanoparticles; optical and morphological characterization; nanoheterostructures
Dr. Nicoletta Depalo
Guest Editor
National Research Council, Institute for Chemical-Physical Processes (CNR-IPCF) 70126 Bari, Italy
Interests: colloidal inorganic nanomaterials functionalization; lipid- and polymer-based nanosystems; drug delivery nanovectors; multifunctional targeted nanostructures; theranostics

Special Issue Information

Dear Colleagues,

Colloidal nanoparticles are transforming many research fields, from energy conversion to biomedicine. The size/shape- and composition-dependent physicochemical properties of inorganic materials and their large surface area, which regulates interaction at the interface, highlight the strong relationship between structure and property (hence function) at the nanoscale and push towards a selective design of the materials. In this regard, colloidal nanoparticles that are synthesized in solution can take advantage of the principles of colloidal chemistry for the development of synthetic strategies able to offer a high control of their morphology, composition, and surface chemistry. Since these artificial colloidal nanoparticles are dispersible in solution, they can be manipulated like molecules, and molecular reaction or interaction can be specifically exploited for the material’s surface functionalization. In this regard, this Special Issue aims at highlighting diverse aspects of materials at the nanoscale, spanning from the synthesis of different classes of colloidal nanoparticles to their surface engineering, towards properly designed nanostructures with tailored functional properties and, consequently, as active components that can be useful for applications in the field of energy conversion, catalysis, sensing, and biomedicine. We want to encourage scientists of diverse backgrounds (material science, inorganic chemistry, biochemistry, biology) to contribute cutting-edge research papers, communications, and review articles to this Special Issue of Nanomaterials.

Dr. Elisabetta Fanizza
Dr. Nicoletta Depalo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • colloidal nanoparticles
  • properties at the nanoscale
  • inorganic and organic nanostructures
  • nanoparticles engineering
  • multifunctional nanosystems

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Silica nanoparticles as inner-sphere ligands of Co2+ ions. Impact of synthetic technique on geometry of inner-sphere polyhedron and electrochemical activity of the nanoparticles
Authors: Olga Bochkova; Michael Khrizanforov; Aidar Gubaidullin; Tatiana Gerasimova; Irek Nizameev; Kirill Kholin; Yulia Budnikova; Asiya Mustafina
Affiliation: Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzov str., 8, 420088, Kazan, Russia
Abstract: The present work introduces both synthesis of silica nanoparticles doped with CoII ions by means of differently modified microemulsion water-in-oil and Stöber techniques and characterization of the hybrid nanoparticles ([email protected]) by TEM, DLS, XRD, ICP-EOS, SAXS, UV-Vis and UV-Vis/DR spectroscopy and electrochemical methods. The results reveal the lack of any nanocrystalline dopants inside the hybrid nanoparticles, as well as no ligands, when CoII ions are added to the synthetic mixtures as CoII(bpy)3 complexes, thus, pointing to coordination of CoII ions with silica matrix as the main driving force of the doping. The use of microemulsion or Stöber technique is of great impact on cobalt content and surface porosity of the hybrid nanoparticles. Comparison of UV-Vis/DR spectra also revealed the difference in the spectral patterns of [email protected] synthesized by the different techniques. The aforesaid differences are correlated with electrochemical activity of CoII ions, which is greatly enhanced by organophosphorus compounds. Its application for the determination of organophosphorus compounds is also demonstrated.

Title: Multifunctional non-epitaxial Nanostructures for diagnosis and therapy
Authors: Elisabetta Fanizza; Nicoletta Depalo
Affiliation: Dipartimento di Chimica, Università degli Studi di Bari Aldo Moro, Italy; National Research Council, Institute for Chemical-Physical Processes SS Bari, Italy
Abstract: Well-designed combination of two or more inorganic nanoparticles (NPs) in a single hierarchically organized nanostructure allows the simultaneous exploitation of multiple properties, such as luminescence, photo-activity or magnetism, deriving from each component. Two main preparative approaches can been explored for the preparation of the multidomain nanomaterials: the epitaxial growth of a second domain onto seeds of pre-existing one and the non-epitaxial growth. While the epitaxial growth requires advances in solution-based synthesis and heterostructure properties are strongly affected by lattice mismatch at the two domains interface, the non-epitaxial growth generates the complex hybrid nanostructures by simply joining and assembling discrete groups of distinct pre-synthesized NPs, regardless of structural parameters of each single NP. Bridging molecules, interacting surface moieties/ligands, or glues via polymer sections can be used for this purpose. This review intends to give an overview of the main preparative strategies and properties of non-epitaxial nanostructures proposed for applications in biomedicine. Indeed, multicomponent nanostructures can be functionalized with specific biomolecules to achieve original bioconjugates with great potential in diagnosis and/or therapy of several diseases. The NPs properties will be extensively described, to better understand the effective advantage offered by each individual function when integrated in a single nanostructure. Representative examples of bifunctional (magnetic/plasmonic, or magnetic/fluorescent or plasmonic/fluorescent) non epitaxial nanostructures, investigated for diagnosis and therapy of specific diseases, will be presented and listed according to the strategy used to assemble the discrete groups of distinct NPs.

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