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Nanomaterials
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Latest Research on Nanomedicine and Drug Delivery Using Inorganic Nanoparticles
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Latest Research on Nanomedicine and Drug Delivery Using Inorganic Nanoparticles

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (15 May 2026) | Viewed by 2955

Special Issue Editors

Dr. Sandra Jiménez-Falcao

E-Mail Website
Guest Editor
Departamento Materiales y Producción Aeroespacial, ETSI Aeronáutica y del Espacio, Universidad Politécnica de Madrid, 28040 Madrid, Spain
Interests: nanomaterials; drug release; inorganic nanomaterials; polymers; enzymes
Dr. Alejandro Baeza

E-Mail Website
Guest Editor
Dpto. Materiales y Producción Aeroespacial, ETSI Aeronáutica y del Espacio, Universidad Politécnica de Madrid, 28040 Madrid, Spain
Interests: nanomaterials; immunotherapy; inorganic nanomaterials; polymers; enzymes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, nanomedicine has experienced an incredible revolution, owing to the development of advanced nanoparticles used as nanocarriers able to perform both delivery and therapeutic tasks, besides participating in recognition events useful for sensing purposes. In this context, inorganic nanoparticles are of special interest because of their versatility in terms of chemical and physical features. Thus, we are pleased to invite you to contribute to this Special Issue by providing your latest research about this field.

The aim of this Special Issue is to bring light to cutting-edge technologies that contribute to the development of the nanomedicine field based on inorganic nanoparticles like silica, metal, or metal oxide nanoparticles. Novel synthetic procedures, original nanoarchitectures with advanced features or innovative applications, are a subject to be considered in this Special Issue. We intend to enlarge knowledge about all the possibilities that inorganic nanoparticles can bring to a variety of diseases and health issues that need to be urgently addressed.

We look forward to receiving your contributions!

Dr. Sandra Jiménez-Falcao
Dr. Alejandro Baeza
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • inorganic nanoparticles
  • hybrid nanomaterials
  • metal oxide nanoparticles
  • metal nanoparticles
  • silica nanoparticles
  • drug release
  • sensing
  • theranostics

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Published Papers (3 papers)

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Research

16 pages, 5475 KB  
Article
A Facile Nanocarrier for Paclitaxel Delivery Based on Carboxymethyl Chitosan Encapsulated 6-Deoxy-6-Mercapto-β-Cyclodextrin Grafted Concave Cubic Gold
by Hao Li, Lin Zhang, You Long, Chao Shen, Song Zhang, Fang Chen, Nan Chen and Chenghong Huang
Nanomaterials 2026, 16(6), 378; https://doi.org/10.3390/nano16060378 - 21 Mar 2026
Viewed by 489
Abstract
Paclitaxel is a first-line anticancer drug, but its low water solubility impedes bioavailability. The purpose of this study is to estalish a delivery strategy via carboxymethyl chitosan (CMCS)-encapsulated 6-deoxy-6-mercapto-β-cyclodextrins (dmβCDs)-modified concave cubic gold (CCGs) to achieve PTX release. CCGs were initially synthesized by [...] Read more.
Paclitaxel is a first-line anticancer drug, but its low water solubility impedes bioavailability. The purpose of this study is to estalish a delivery strategy via carboxymethyl chitosan (CMCS)-encapsulated 6-deoxy-6-mercapto-β-cyclodextrins (dmβCDs)-modified concave cubic gold (CCGs) to achieve PTX release. CCGs were initially synthesized by the one-pot method and further modified by dmβCDs, the dmβCDs can effectively capture PTX molecules, followed by encapsulation with CMCS, and then prepare pH-responsive CMCS/dmβCDs/CCGs nanocarriers after lyophilization. Results indicated that desirable hexagonal CCGs with 50 ± 5 nm size can be obtained by adjusting H2O2 and HClO concentration. FT-IR, Raman and XRD spectra had confirmed dmβCDs successfully grafted to the surface of CCGs. Drug loading experiments demonstrated that the nanocarrier encapsulated PTX in amorphous powder or molecular form have a capacity of 55.05 µg/mL. Drug release experiments revealed PTX release from CMCS/dmβCDs/CCGs nanocarriers carrying a typical pH-responsive profile and indicating earlier release in an acidic environment than in a neutral or alkaline environment. The proposed method can be utilized to effectually achieve high-efficiency solubilization and targeted release inside tumor cells of PTX. Full article
(This article belongs to the Special Issue Latest Research on Nanomedicine and Drug Delivery Using Inorganic Nanoparticles)
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22 pages, 1787 KB  
Article
Dual Synthetic Pathways for Organotin-Functionalized Mesoporous Silica Nanoparticles: Targeted Therapeutic Platforms with Folic Acid and PEI Formulation
by Victoria García-Almodóvar, Sanjiv Prashar and Santiago Gómez-Ruiz
Nanomaterials 2025, 15(23), 1791; https://doi.org/10.3390/nano15231791 - 27 Nov 2025
Viewed by 828
Abstract
Breast cancer is the most common cancer in women worldwide, with a high mortality rate. Moreover, the treatments currently used to address this disease are sometimes ineffective and cause numerous side effects. For this reason, the search for new treatments that can overcome [...] Read more.
Breast cancer is the most common cancer in women worldwide, with a high mortality rate. Moreover, the treatments currently used to address this disease are sometimes ineffective and cause numerous side effects. For this reason, the search for new treatments that can overcome these challenges is a growing field of research. One potential solution under investigation is the use of mesoporous silica nanoparticles (MSNs). These materials possess excellent properties, making them attractive as starting platforms for various compounds. In this study, different compounds with distinct properties were anchored onto these nanoplatforms. The first is polyethyleneimine (PEI), which, when formulated within the nanoparticle, increases its bioavailability. The second is folic acid (FA), a molecule that enables active targeting of tumor cells. Finally, an organotin(IV) complex was incorporated via two different anchoring strategies to provide therapeutic action. This multifunctional platform thus combines three activities simultaneously. MTT assay studies revealed that the final material, MSN-TEDTH-PEI-FA-TR-Sn, demonstrates potential against the MCF-7 tumor cell line while showing no toxicity to the healthy Hek 293T cell line. These findings make it an interesting candidate for future in vivo trials. Full article
(This article belongs to the Special Issue Latest Research on Nanomedicine and Drug Delivery Using Inorganic Nanoparticles)
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19 pages, 3110 KB  
Article
Low-Cost Versatile Microfluidic Platform for Bioorthogonal Click-Mediated Nanoassembly of Hybrid Nanosystems
by Javier González-Larre, María Amor García del Cid, Diana Benita-Donadios, Ángel Vela-Cruz, Sandra Jiménez-Falcao and Alejandro Baeza
Nanomaterials 2025, 15(21), 1663; https://doi.org/10.3390/nano15211663 - 1 Nov 2025
Viewed by 977
Abstract
In recent years the global market of nanomedicine has experienced incredible growth owing to the advances in the field. This translation of the technique to the biomedical industry requires the development of production methods that deliver nanomedicines with a high degree of reproducibility [...] Read more.
In recent years the global market of nanomedicine has experienced incredible growth owing to the advances in the field. This translation of the technique to the biomedical industry requires the development of production methods that deliver nanomedicines with a high degree of reproducibility between batches, combined with cost and time efficiency. The use of nanoparticles in medicine usually requires their surface functionalization to improve biocompatibility in addition to providing targeting capacities and/or stimuli-responsive behavior, among other interesting skills. Microfluidic technology has revolutionized the field both in nanomedicine synthesis and in preclinical evaluation. However, microfluidic-assisted synthetic procedures commonly require high-cost methods and equipment to fabricate the microreactors. The aim of this work is to present an ultra-low-cost microfluidic platform that permits the versatile modification of nanomaterials. To prove this approach, two different model nanoparticles with different natures: soft nanoparticles (liposomes) and rigid nanoparticles (mesoporous silica) have been decorated both with small molecules and with other nanoparticles, respectively, in order to evaluate the scope of this approach. The anchoring of the covalently attached elements has been performed using click chemistry, in compliance with the principles for further transfer to the drug industry. Full article
(This article belongs to the Special Issue Latest Research on Nanomedicine and Drug Delivery Using Inorganic Nanoparticles)
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