Advances in Nanobiotechnology and Nanobiophysics: Innovations and Methodological Breakthroughs in Atomic Force Microscopy
A special issue of Nanomaterials (ISSN 2079-4991).
Deadline for manuscript submissions: 12 December 2025 | Viewed by 12
Special Issue Editor
Interests: nanorheology of living cells; naoscale imaging of living organisms; nanomaterials; atomic force microscopy and spectroscopy; Raman spectroscopy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Nanobiotechnology and nanobiophysics are rapidly evolving fields driven by the development of innovative, advanced, and novel techniques, with Atomic Force Microscopy (AFM) being one of the most used and continuously developing methods. The wide applications of AFM in both nanobiotechnology and nanobiophysics originate from the ability of AFM to create high-resolution images of and manipulate, at the nano scale, biological samples, allowing for the investigation of their morphology and mechanics, as well as their interactions, under physiological conditions. Furthermore, AFM can be combined with other microscopy and spectroscopy techniques to obtain a deeper and more thorough understanding of highly complex biological systems. Although AFM is largely employed in both nanobiotechnology and nanobiophysics, its scopes and benefits differ. In nanobiotechnology, AFM is used for investigating and manipulating biomolecules and cell/tissue surfaces, as well as characterizing nanoparticles. In nanobiophysics, the applications of AFM concern the study of cell and biomolecules mechanics/morphology, the physical properties of cell membranes, and the interactions between biological systems.
The aim of this Special Issue, titled ‘Advances in Nanobiotechnology and Nanobiophysics: Innovations and Methodological Breakthroughs in Atomic Force Microscopy’, is to explore the latest advances and methodological breakthroughs in the applications of AFM in biotechnological areas such as gene editing, drug delivery systems, protein folding, cell/biomolecule mechanics and imaging, and in biophysics (e.g., protein dynamics, molecular/cellular interactions, and the surface characterization of biomaterials and membranes). This Special Issue welcomes original research articles and review papers and topics of interest including, but not limited to, the advances, innovations, and methodological breakthroughs of AFM in biotechnology and biophysics in the following areas:
- AI-enhanced AFM;
- Advanced and novel drug delivery systems;
- Innovative gene editing/diagnostics;
- AI-driven drug development;
- Protein dynamics and interactions;
- Regenerative medicine;
- Tissue engineering;
- Combinations of AFM with other techniques.
Dr. Elisabetta Canetta
Guest Editor
Manuscript Submission Information
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Keywords
- atomic force microscopy
- protein dynamics
- biomolecules mechanics
- cell mechanics
- membrane biophysics
- artificial intelligence
- regenerative medicine
- gene editing
- drug development
- drug delivery
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