Probing Single Events at the Nanoscale

Dear Colleagues,

Recent developments on time and spatially resolved analytical techniques have opened new avenues for understanding the processes and properties of materials and living systems at the nanoscale with unprecedented levels of sensitivity and reliability. Non-linear optical methods have allowed for the flourishing of multi-photon fluorescence microscopes able to probe sub-micron events in complex biological systems. Correlative microscopy techniques, combining electron microscopy, optical microscopy, and nanoparticle bio-conjugates, have advanced further the forefront of research by enabling ultra-resolution imaging of subcellular processes down to single molecular interactions. Indirect plasmonic sensing has emerged as a reliable technique for probing processes at the single nanoparticle level, while consolidated analytical chemistry methods, such as inductively coupled plasma mass spectrometry (ICP-MS), have also reached single-particle sensitivity and diversified into spatially resolved modes by incorporating laser ablation techniques. Other areas of research, focused on structural characterization of materials and molecules, have benefitted enormously from analytical methods based on high intense synchrotron radiation, cryo electron microscopy (cryo-TEM and cryo-SEM), and scanning tunneling microscopy (STM). The scientific community is facing a revolution centered on the need for reliable probing of single nano-events and correlating them with bulk observables of technological relevance. This Special Issue of Nanomaterials will cover the emerging field of “Probing Single Events at the Nanoscale”, providing a broad and inclusive forum at the interface between nanotechnology, analytical chemistry, structural biology, and engineering of microscopy tools. We welcome research articles, literature reviews, and perspective papers that could contribute to this exciting research field.

Dr. Yuri Diaz Fernandez
Guest Editor

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