Nanomaterials for Biomedical and Environmental Applications
A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".
Deadline for manuscript submissions: closed (31 March 2025) | Viewed by 1873
Special Issue Editors
Interests: nanomaterials; dendrimers; macromolecules; hydrogels for biomedical and environmental applications; resins; polymeric drug delivery systems; organic synthesis; antibacterial and/or antitumor cationic macromolecules; solubilizing agents; cationic bola-amphiphiles
Special Issues, Collections and Topics in MDPI journals
Interests: retinoids; drug delivery systems; polymeric micelles; liposomes; passive targeting; active targeting; poorly soluble drugs; formulation strategies; cancer; neuroblastoma; melanoma; tumor mouse models; oncology; apoptosis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Nanomaterials, including nanoparticles, dendrimers, nanosized micelles, liposomes, etc. possess nonpareil properties, and at present, they find a plethora of applications in several sectors. Among them, synthetic bola-amphiphiles (BAs) are molecules mimicking archaeal membrane lipids. Traditionally, BAs bear two or more, equal or different, polar head groups linked by one or more hydrophobic chains. Inverted BAs featuring a polar central spacer flanked by nonpolar head groups have also been reported. Non-ionic BAs with dendritic capping with a high molecular weight have also been discovered. Bas, like other nanomaterials possess nonpareil colloidal properties able to self-assemble in solution in nanosized micelles capable of entrapping drugs, thus enhancing their solubility and stability or reducing toxicity. The assembled structures formed by BAs in solution are complex and thus require further in-depth analysis. Although reviews exist summarizing the synthetic methods to prepare BAs, their self-assembling ability and their use as pore-forming and electron-conducting materials, drug delivery systems, hydrogels constituents, and cell membrane-active compounds effective against both pathogens and cancer—in addition to several other applications such as those relating to the environment—are still insufficiently explored. Research involving BAs as active components of a more complex formulation is expanding. At present, BAs are also studied in gene delivery, where multicomponent lipid nano-formulations are common. The goal of this Special Issue is to collect contributions, including full articles, reviews, featured articles, communications, and reports, on the development of all types of nanomaterials with a special focus on BAs and their applications in the biomedical and environmental fields.
Prof. Dr. Silvana Alfei
Prof. Dr. Guendalina Zuccari
Guest Editors
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Keywords
- bola-amphiphiles
- bola-amphiphilic hydrogels
- self-forming nanosized vesicles
- colloidal properties
- self-forming micelles
- bis-phosphonium salts
- bis-triphenyl phosphonium groups
- mitochondria-targeted bola-amphiphiles
- membrane permeabilization
- drug delivery systems
- gene delivery
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