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Nanomaterials
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Applications of Nanomaterials in Biomedical Imaging and Cancer Therapy: 4th...
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Applications of Nanomaterials in Biomedical Imaging and Cancer Therapy: 4th Edition

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: 20 March 2026 | Viewed by 325

Special Issue Editor

Prof. Dr. James C. L. Chow

E-Mail Website
Guest Editor
Department of Radiation Oncology, University of Toronto, Toronto, ON M5T 1P5, Canada
Interests: nanotechnology; nanoparticle-enhanced radiotherapy; nanotheranostic; computer simulation; machine learning; chatbot; cancer therapy; radiation dosimetry; FLASH radiotherapy; quantum computing
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Following the tremendous success of the third edition of our Special Issue, entitled “Applications of Nanomaterials in Biomedical Imaging and Cancer Therapy: 3rd Edition”, in which a total of seven papers were published (https://www.mdpi.com/journal/nanomaterials/special_issues/Z0U20L95FF), we are pleased to launch a fourth edition.

Our first three successful editions of this Special Issue received a collection of excellent works on applying nanomaterials and nanotechnology in biomedical imaging and cancer therapy. We recognized that it was timely and necessary to launch a platform to share researchers’ studies in order to keep pace with the recent technological changes in nanomaterials and nanotechnology. Therefore, we are pleased to invite you to submit your research works to this new edition, focusing on studies using nanomaterials as enhancers in targeted therapy and precise imaging. Research papers we are interested in include, but are not limited to, those presenting developments in imaging agents and enhancers in cancer therapy, experimental results from cellular, preclinical, and clinical studies, drug nanocarriers, and computational methods/simulations of the interaction between nanomaterials and cell/DNA targets. This Special Issue aims to continue the success of our previous Special Issues, and we welcome the submission of original research articles, technical reports, and reviews.

We look forward to receiving your contributions.

Prof. Dr. James C. L. Chow
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterials
  • biomedical imaging
  • cancer therapy
  • nanoparticles
  • targeted drug delivery
  • photothermal therapy
  • photodynamic therapy
  • quantum dots
  • drug nanocarrier
  • theranostics

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Published Papers (1 paper)

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Research

18 pages, 9321 KB  
Article
One-Step Ambient-Condition Synthesis of PEG- and PVA-Coated SPIONs: Morphological, Magnetic, and MRI Performance Assessment
by Laura Turilli, Angelo Galante, Franco D’Orazio, Valeria Daniele and Giuliana Taglieri
Nanomaterials 2025, 15(24), 1902; https://doi.org/10.3390/nano15241902 - 18 Dec 2025
Viewed by 179
Abstract
Superparamagnetic iron oxide nanoparticles (SPIONs) are commonly produced through wet-chemical methods that require high temperature and pressure and involve multiple synthesis steps. Our research group has developed an innovative, sustainable, and patented one-step aqueous synthesis operating at ambient temperature and pressure, enabling the [...] Read more.
Superparamagnetic iron oxide nanoparticles (SPIONs) are commonly produced through wet-chemical methods that require high temperature and pressure and involve multiple synthesis steps. Our research group has developed an innovative, sustainable, and patented one-step aqueous synthesis operating at ambient temperature and pressure, enabling the direct production of SPIONs in suspension. In this work, we investigated the extension of this method to obtain polymer-coated SPIONs for biomedical imaging applications. Two water-soluble and biocompatible polymers—poly(ethylene glycol) (PEG) and poly(vinyl alcohol) (PVA)—were selected and prepared into twelve samples varying in polymer concentration and iron precursor molarity. Each formulation was characterized and compared to bare SPIONs synthesized with the same approach using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM), and alternating gradient magnetometry (AGM). The results confirm that the one-step method yields polymer-coated nanoparticles with a cubic spinel magnetite core. PEG produced spherical, monodisperse particles (10–30 nm) exhibiting superparamagnetic behavior but lower magnetization values (1–5 emu/g). In contrast, PVA-coated nanoparticles showed a morphology dependent on polymer concentration and reagent molarity, while maintaining an average size of ~10 nm and superparamagnetic behavior, with magnetization comparable to bare SPIONs (25–50 emu/g). A preliminary MRI evaluation of a selected PVA-coated sample revealed relaxivity values of r1 = 0.12 mM−1 s−1 and r2 = 6.44 mM−1 s−1, supporting the potential of this synthesis route for imaging-oriented nanomaterials. Full article
(This article belongs to the Special Issue Applications of Nanomaterials in Biomedical Imaging and Cancer Therapy: 4th Edition)
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