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Nanomaterials
Special Issues
Advanced Nanomaterials for Bioimaging: 2nd Edition
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Advanced Nanomaterials for Bioimaging: 2nd Edition

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: 20 December 2025 | Viewed by 2124

Special Issue Editor

Prof. Dr. Gangho Lee

E-Mail Website
Guest Editor
Department of Chemistry, Kyungpook National University, Daegu 41566, Republic of Korea
Interests: nanomaterials; nanomaterial synthesis; imaging agents; nanomedicine; contrast agents; nanoparticle colloid; surface modification
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nanomaterials such as nanoparticles, nanorods, core–shell nanoparticles, and hybrid nanoparticles have been extensively studied for various biomedical applications. Among them, their applications as imaging agents in magnetic resonance imaging (MRI), X-ray computed tomography (CT), fluorescent imaging (FI), and acoustic imaging (AI) are of special interest because of their imaging properties, which are superior to conventional molecular imaging agents. Until now, there have been countless reports regarding imaging agents made of nanomaterials (i.e., metal oxide nanomaterials, metal nanomaterials, and nonmetal nanomaterials), demonstrating their unique and advanced properties which will be extremely useful for the diagnosis of diseases.

The aim of this Special Issue is to report a variety of imaging agents made of nanomaterials that have already been reported. These include the synthesis of nanomaterials using various techniques, surface modifications, characterizations, and in vitro and in vivo applications as imaging agents. Particle size and shape affect imaging properties; thus, their control is very important for the successful application of nanomaterials as imaging agents. Surface modification with hydrophilic ligands is essential for their biomedical applications as imaging agents. The further functionalization of the surface-modified nanomaterials with functional molecules such as drugs and cancer-targeting ligands will allow them to be used as cancer-targeting theragnostic agents. This Special Issue will cover a variety of nanomaterials which can be applied to MRI, CT, FI, and AI as imaging agents.

Prof. Dr. Gangho Lee
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterial
  • nanoparticle
  • nanorod
  • core–shell nanomaterial
  • imaging agent
  • magnetic resonance imaging
  • X-ray computed tomography (CT)
  • fluorescent imaging
  • acoustic imaging
  • theragnostic agent

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Related Special Issue

Published Papers (3 papers)

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Research

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17 pages, 1429 KB  
Article
Synthesis and Characterization of a Nanoscale Hyaluronic Acid-Specific Probe for Magnetic Particle Imaging and Magnetic Resonance Imaging
by Harald Kratz, Dietmar Eberbeck, Frank Wiekhorst, Matthias Taupitz and Jörg Schnorr
Nanomaterials 2025, 15(19), 1505; https://doi.org/10.3390/nano15191505 - 1 Oct 2025
Viewed by 350
Abstract
Glycosaminoglycans (GAGs) are part of the extracellular matrix (ECM) and play a major role in maintaining their physiological function. During pathological processes, the ECM is remodeled and its GAG composition changes. Hyaluronic acid (HA) is one of the GAGs that plays an important [...] Read more.
Glycosaminoglycans (GAGs) are part of the extracellular matrix (ECM) and play a major role in maintaining their physiological function. During pathological processes, the ECM is remodeled and its GAG composition changes. Hyaluronic acid (HA) is one of the GAGs that plays an important role in pathological processes such as inflammation and cancer and is therefore an interesting target for imaging. To provide iron oxide nanoparticles (IONP) that bind to hyaluronic acid (HA) as specific probes for molecular imaging, a peptide with high affinity for HA was covalently bound to the surface of commercial IONP (synomag®-D, NH2) leading to hyaluronic acid-specific iron oxide nanoparticles (HAIONPs). Affinity measurements using a quartz crystal microbalance (QCM) showed a very high affinity of HAIONP to HA, but not to the control chondroitin sulfate (CS). HAIONPs exhibit a very high magnetic particle spectroscopy (MPS) signal amplitude, which predestines them as HA-selective tracers for magnetic particle imaging (MPI). The high relaxivity coefficient r2 also makes HAIONP suitable for magnetic resonance imaging (MRI) applications. HAIONP therefore offers excellent prerequisites for further development as a probe for the specific quantitative imaging of the HA content of the ECM in pathological areas. Full article
(This article belongs to the Special Issue Advanced Nanomaterials for Bioimaging: 2nd Edition)
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Review

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29 pages, 4897 KB  
Review
Review of Current Achievements in Dendrimers and Nanomaterials for Potential Detection and Remediation of Chemical, Biological, Radiological and Nuclear Contamination—Integration with Artificial Intelligence and Remote Sensing Technologies
by Agnieszka Gonciarz, Robert Pich, Krzysztof A. Bogdanowicz, Witalis Pellowski, Jacek Miedziak, Sebastian Lalik, Marcin Szczepaniak, Monika Marzec and Agnieszka Iwan
Nanomaterials 2025, 15(18), 1395; https://doi.org/10.3390/nano15181395 - 10 Sep 2025
Viewed by 393
Abstract
Current scientific and technological developments indicate that the need for dendrimers and nanomaterials should be taken into account in aspects such as the detection and remediation of chemical, biological, radiological and nuclear (CBRN) contamination. To evaluate the benefits of dendrimers in CBRN contamination, [...] Read more.
Current scientific and technological developments indicate that the need for dendrimers and nanomaterials should be taken into account in aspects such as the detection and remediation of chemical, biological, radiological and nuclear (CBRN) contamination. To evaluate the benefits of dendrimers in CBRN contamination, different characterization methods, toxicological evaluation, and recyclability must be used. The aim of this article is to systematize knowledge about selected nanomaterials and dendrimers as well as chemical, biological, radiological and nuclear (CBRN) hazards in accordance with the principles of green chemistry, engineering, technology and environmental safety. So far, many review articles on dendrimers and nanomaterials have focused on biomedical applications or environmental remediation. In this article, we discuss this topic in more detail, especially in relation to the integration of dendrimers with artificial intelligence and remote sensing technologies. We highlight interdisciplinary synergies—artificial intelligence for smarter design and remote sensing for deployment—that could bridge the gap between nanoscale innovation and real CBRN countermeasures. Full article
(This article belongs to the Special Issue Advanced Nanomaterials for Bioimaging: 2nd Edition)
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32 pages, 6274 KB  
Review
Current Status and Future Aspects of Gadolinium Oxide Nanoparticles as Positive Magnetic Resonance Imaging Contrast Agents
by Endale Mulugeta, Tirusew Tegafaw, Ying Liu, Dejun Zhao, Xiaoran Chen, Ahrum Baek, Jihyun Kim, Yongmin Chang and Gang Ho Lee
Nanomaterials 2025, 15(17), 1340; https://doi.org/10.3390/nano15171340 - 1 Sep 2025
Viewed by 1119
Abstract
Although numerous studies have investigated gadolinium oxide (Gd2O3) nanoparticles (NPs) as positive (T1) magnetic resonance imaging (MRI) contrast agents (CAs), comprehensive reviews on this topic remain scarce. Therefore, it is essential to evaluate their current status and [...] Read more.
Although numerous studies have investigated gadolinium oxide (Gd2O3) nanoparticles (NPs) as positive (T1) magnetic resonance imaging (MRI) contrast agents (CAs), comprehensive reviews on this topic remain scarce. Therefore, it is essential to evaluate their current status and outline prospects. Despite promising physicochemical properties such as considerably higher relaxivities compared to 3–5 s−1mM−1 of clinically approved Gd(III)-chelate contrast agents and encouraging results from in vivo animal studies such as highly improved contrast enhancements, drug loading, and tumor targeting, extensive in vivo toxicity assessments including long-term toxicity and formulation advancements suitable for renal excretion (d < ~3 nm) are still required for clinical translation. This review summarizes the synthesis, characterization, in vitro and in vivo toxicity, and in vivo MRI applications of surface-modified Gd2O3 NPs as T1 MRI CAs. Finally, future perspectives on the development of surface-modified Gd2O3 NPs as potential next-generation T1 MRI CAs are discussed. Full article
(This article belongs to the Special Issue Advanced Nanomaterials for Bioimaging: 2nd Edition)
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