Special Issue "Versatile Coumarins"
Deadline for manuscript submissions: closed (15 August 2017)
Emeritus Prof. Perry T. Kaye
Department of Chemistry, Rhodes University, Grahamstown, South Africa
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Interests: synthetic methodology: Applications of the Baylis–Hillman reaction in the synthesis of benzannulated heterocyclic systems and their elaboration to biologically active compounds; medicinal chemistry: Design, synthesis and in silico and in vitro evaluation of the medicinal potential of novel compounds as anti-parasitic (anti-malarial and anti-trypanosomal), HIV-1 PR, IN and RT inhibitors and anti-TB agents; physical organic chemistry: Kinetic-mechanistic studies of organic reaction mechanisms using spectroscopic and computational methods
Since the isolation of Daphnin from Daphne alpina in 1812 and of coumarin itself from the Tonka bean (Dipteryx odorata) shortly afterwards in 1820; coumarin derivatives have been discovered in a wide variety of plants. Coupled with the variety of natural sources has been the remarkable range of biological activities that coumarin-containing phytochemicals have been observed to exhibit, and such activities have undoubtedly contributed to their use in herbal remedies. Various classes of coumarin derivatives, including 4-hydroxycoumarins, furanocoumarins, and pyranocoumarins, have been identified and synthetic methods continue to be developed to access both the natural products and structural analogues. The broad medicinal potential of coumarin derivatives as, inter alia, anti-coagulant, anti-inflammatory, anti-oxidant, antibiotic, anti-fungal, anti-cancer, anti-diabetic and anti-HIV agents, makes the coumarin nucleus an attractive platform for the development of novel therapeutic agents.
This Special Issue will focus on recent developments in the synthesis or isolation of new coumarin derivatives and their potential as drug discovery lead compounds. Colleagues are invited to submit contributions to research in this area.
Emeritus Prof. Perry T. Kaye
Manuscript Submission Information
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- Drug discovery
- Medicinal Chemistry