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Molecules
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Electrochemical Biosensors: From Design to Application, 2nd Edition
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Electrochemical Biosensors: From Design to Application, 2nd Edition

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Electrochemistry".

Deadline for manuscript submissions: closed (31 October 2025) | Viewed by 914

Special Issue Editors

Dr. Jiao Zhai

E-Mail Website
Guest Editor
Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, China
Interests: electrical-based microfluidic for biological analysis; nanomaterials; nanomedicine
Special Issues, Collections and Topics in MDPI journals
Dr. Yanwei Jia

E-Mail Website
Guest Editor
State Key Laboratory of Analog and Mixed-Signal VLSI, Institute of Microelectronics, University of Macau, Macau, China
Interests: digital microfluidics; DNA identification; drug screening; precision medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

An electrochemical biosensor is a typical sensor device based on converting biochemical data such as concentrations of analytes into detectable electrical signals (e.g., voltage, current.) Electrochemical biosensors typically include three integrated components: a biorecognition element (interact with analyte specifically), a transducer (generate a measurable signal from the analyte–biomolecule interactions), and an electronic system for data management. Due to their small size, portability, ease of use, and small required sample volume and cost effectiveness, electrochemical biosensors are very useful tools for detecting low levels of target cancer biomarkers in biological fluids. In recent years, electrochemical biosensors have been integrated into Point-of-Care Testing Devices for pathogen detection, food detection, environment monitoring and healthcare monitoring.

This Special Issue will study electrochemical biosensor technologies, ranging from innovative sensor design to biochemical applications (e.g., biochemical analysis, healthcare monitoring, food detection, pathogen detection.). This Special Issue will gather original articles and reviews showing the latest research, innovative fabrication and biochemical applications, new challenges, and future perspectives regarding electrochemical biosensor technologies.

Dr. Jiao Zhai
Dr. Yanwei Jia
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • electrochemical sensor
  • bioanalysis
  • pathogen detection
  • healthcare monitoring
  • food detection

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Published Papers (1 paper)

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Review

24 pages, 1353 KB  
Review
Electrochemical Lateral Flow Platforms: Pioneering the Future of Rapid Testing
by Joao P. R. S. Carvalho, Isis C. Prado, Karyne Rangel, Jessica A. Waterman and Salvatore G. De-Simone
Molecules 2026, 31(8), 1305; https://doi.org/10.3390/molecules31081305 - 17 Apr 2026
Viewed by 488
Abstract
The increasing demand for advanced diagnostic technologies has positioned biosensor platforms as powerful alternatives to conventional analytical methods. Among them, lateral flow platforms (LFPs) are widely used for their speed, simplicity, and low cost. However, their limited sensitivity and lack of quantitative precision [...] Read more.
The increasing demand for advanced diagnostic technologies has positioned biosensor platforms as powerful alternatives to conventional analytical methods. Among them, lateral flow platforms (LFPs) are widely used for their speed, simplicity, and low cost. However, their limited sensitivity and lack of quantitative precision have spurred the development of enhanced systems incorporating electrochemical detection. Electrochemical biosensors offer significant advantages, including high sensitivity, excellent selectivity, and ease of miniaturization, which make them especially suitable for point-of-care testing (POCT). To address the limitations of traditional colorimetric LFPs, several strategies have been employed, such as the incorporation of nanomaterials, enzymatic amplification, and signal-enhancing labels. A particularly promising innovation is the direct integration of electrodes into LFPs, enabling real-time electrochemical readouts and enhanced analytical accuracy. Despite their potential, challenges persist, including manufacturing complexity, a lack of standardized protocols, and difficulties in scaling production for widespread adoption. Continued progress in developing hybrid platforms that combine lateral flow technology with electrochemical detection is crucial for expanding diagnostic applications in healthcare, environmental monitoring, and food safety. This work explores recent advances in electrochemical LFPs, reviewing current methodologies while discussing their advantages, limitations, and the future directions necessary to facilitate broader implementation and improve global diagnostic accessibility. Full article
(This article belongs to the Special Issue Electrochemical Biosensors: From Design to Application, 2nd Edition)
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