The Role of Phosphorus in Drug Discovery

Dear Colleagues,

Currently, a relatively small number of clinically validated human therapeutics contain phosphorus. Synthetic challenges associated with phosphorus chemistry may play a role in discouraging medicinal chemists from exploring such molecules. Therefore, this area of research could provide new opportunities for structural diversity and novel functional groups for medicinal chemistry. The main aims of this Special Issue on "The Role of Phosphorus in Drug Discovery" is to provide an open forum where researchers may share their investigations and findings in this important field of medicinal chemistry. Contributions to this Special Issue, in the form of original research or review articles, may cover any aspect of drug discovery that may highlight the biopharmaceutical advantages or disadvantages of phosphorus-containing drug candidates. Because drug discovery is inherently a multidisciplinary endeavor, manuscripts offering new insights on the overall biopharmaceutical properties of phosphorus-containing compounds, are particularly welcome.

Prof. Youla S. Tsantrizos
Guest Editor

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