Phenotypic Drug Discovery
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (31 March 2020) | Viewed by 11949
Special Issue Editor
Interests: anticancer compounds; drug discovery; drug design; phenotypic assays; mechanism of action; chemical databases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The challenge in a phenotypic drug discovery strategy is to fully understand and elucidate, in addition to the resolution of the mechanism of action with high resolution, the molecular target(s) affected by a small molecule that are responsible for its pharmacological activity. Recently, Bender and co-workers (doi: 10.4155/fmc.14.137) proposed a model that combines three data sources: the chemical structure, the biological routes and the phenotypic responses. Although it is an advance, the model has the limitation of the low statistical significance of the results.
In general, the objective of this Special Issue is to gather contributions from research groups that run phenotypic assays in the discovery of new compounds with pharmacological potential. In particular, manuscripts reporting working models and phenotypic pattern recognition approaches are welcome. There is no restriction in terms of therapeutic areas, although some have been more extensively approached through phenotypic discoveries.
We anticipate that the results of the use of combined experimental and computational data to correlate phenotypic responses will allow the actors involved to design more efficient, faster, less laborious and less expensive strategies for the search of new therapeutic options with small molecules.
Prof. Dr. José M. Padrón
Guest Editor
Manuscript Submission Information
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Keywords
- Drug discovery
- Small molecules
- Phenotypic response
- Mechanism of action
- Target fishing
- Recognition patterns
- Algorithms
- Bioactive conformation
