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Special Issue "Recent Development of Nucleic Acid Analogs"

A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: 30 January 2020

Special Issue Editor

Guest Editor
Prof. Dr. Yoshiyuki Hari

Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Nishihama, Yamashiro-cho, Tokushima 770-8514, Japan
Website | E-Mail
Interests: nucleic acid chemistry, bioorganic chemistry, organic synthesis, medicinal chemistry

Special Issue Information

Dear Colleagues,

Nucleic acid analogs that provide improved properties and/or new functions to DNA or RNA molecules including oligonucleotides are extensively used for investigating the life phenomenon, developing nucleic acid medicines, and creating biotechnologies, etc. For example, fluorescent nucleobases can be used for microenvironmental monitoring and studying dynamic structures of nucleic acids. Nucleobase analogs, forming metal-mediated base pairs or unnatural base pairs, can also be applied to genetic code expansion technology. Besides, cross-linkable nucleic acids, external stimuli-responsive nucleic acids, function-switchable nucleic acids, and RNA mimics including bridged nucleic acids, etc., are also promising materials. Therefore, also because synthetic methodology and the technology of modified DNA/RNA molecules have been making progress, the development of nucleic acid analogs possessing attractive properties will become continuously and increasingly active.

Thus, the aim of this Special Issue is to provide recent attractive and exciting findings concerning nucleic acid analogs. A wide research area ranging from the synthesis to the application of nucleic acid analogs will be covered in this Special Issue. I would like to cordially invite everyone to submit research articles and comprehensive reviews dealing with this research area.

Prof. Dr. Yoshiyuki Hari
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • functional nucleic acids
  • functional oligonucleotides
  • nucleic acid analogs
  • nucleobase analogs
  • nucleoside analogs
  • nucleotide analogs

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Author: Asako Yamayoshi
Type of paper:  research article
Tentative title:  Development of 7SK snRNA mimics that inhibit HIV transcription
Abstract:  7SK, 332nt small nuclear RNA, is a highly conserved non-coding RNA and regulates transcriptional elongation. By binding with P-TEFb (positive transcriptional elongation factor b) via HEXIM1, 7SK reduces kinase activity of P-TEFb and inhibits transcriptional elongation. It is also reported that inhibition of the 7SK lead to the stimulation of HIV-specific transcription. These reports suggest that the 7SK is a naturally occurring functional molecule as negative regulator against P-TEFb and HIV transcription. In this study, we developed functional oligonucleotides that mimic the function of 7SK (7SK-mimic) as a novel inhibitor for HIV-replication. We defined the essential region of 7SK for their transcriptional down-regulation ability by an antisense strategy. And based on the results, we designed 7SK-mimics containing the defined region. Inhibitory effects of 7SK mimics on HIV-1 LTR promoter specific transcription was drastic compared control-mimic molecule. Notably, these effects were more enhanced by co-transfection with Tat-expressing plasmid. So we conclude that 7SK mimics have great therapeutic potential for HIV/AIDS treatment.

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