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Natural Molecules Controlling Lipid Metabolism
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Natural Molecules Controlling Lipid Metabolism

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 23654

Special Issue Editors

Dr. Marek Skrzypski

E-Mail Website
Guest Editor
Department of Animal Physiology, Biochemistry and Biostructure, Poznan University of Life Sciences, 60-637 Poznań, Poland
Interests: adipose tissue; cell biology; diabetes; metabolism; obesity
Special Issues, Collections and Topics in MDPI journals
Dr. Paweł A. Kołodziejski

E-Mail Website
Guest Editor
Department of Animal Physiology, Biochemistry and Biostructure, Poznan University of Life Sciences, 60-637 Poznań, Poland
Interests: diabetes; obesity; fat tissue; pancreas; liver; muscle; metabolic syndrome; cell biology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Lipids play a prominent role in maintaining energy homeostasis and cell signaling and are functional components of cell membranes. However, perturbations in lipid homeostasis are associated with development and progression of numerus diseases such as obesity, metabolic syndrome, type 2 diabetes, or cancer. Moreover, aberrant lipid metabolism was implicated in the pathogenesis of neurodegenerative disorders including Alzheimer’s disease.

Therefore, identification of novel molecules able to affect the lipid metabolism is considered an attractive target for the treatment of a wide range of disorders.

In this Special Issue, we are inviting original works and review articles dedicated to improving the knowledge regarding the role of natural molecules in controlling lipid metabolism in health and diseases. In particular, we are interested in contributions related to role of hormones, nutrients, and substances isolated from natural products and organisms in the regulation of lipid degradation, synthesis, and transport, and their role in cell signaling and cell structure. Original in vitro, animal and human in vivo studies, as well as review manuscripts, will be considered for evaluation.

Dr. Marek Skrzypski
Dr. Paweł A. Kołodziejski
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lipids
  • metabolism
  • natural molecules
  • nutrients
  • energy homeostasis
  • diabetes
  • obesity
  • cancer

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Published Papers (4 papers)

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Research

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20 pages, 3054 KiB  
Article
Acute Stress-Induced Changes in the Lipid Composition of Cow’s Milk in Healthy and Pathological Animals
by Yaiza Garro-Aguilar, Roberto Fernández, Silvia Calero, Ekaterina Noskova, Marina Gulak, Miguel de la Fuente, Albert Adell, Edurne Simón, Urko Muzquiz, Diego Rodríguez-Piñón, Egoitz Astigarraga and Gabriel Barreda-Gómez
Molecules 2023, 28(3), 980; https://doi.org/10.3390/molecules28030980 - 18 Jan 2023
Cited by 2 | Viewed by 2554
Abstract
Producers of milk and dairy products have been faced with the challenge of responding to European society’s demand for guaranteed animal welfare production. In recent years, measures have been taken to improve animal welfare conditions on farms and evaluation systems have been developed [...] Read more.
Producers of milk and dairy products have been faced with the challenge of responding to European society’s demand for guaranteed animal welfare production. In recent years, measures have been taken to improve animal welfare conditions on farms and evaluation systems have been developed to certify them, such as the Welfare Quality® protocol. Among the markers used for this purpose, acute phase proteins stand out, with haptoglobin being one of the most relevant. However, the diagnostic power of these tools is limited and more sensitive and specific technologies are required to monitor animal health status. Different factors such as diet, stress, and diseases modify the metabolism of the animals, altering the composition of the milk in terms of oligosaccharides, proteins, and lipids. Thus, in order to study oxidative-stress-associated lipids, a collection of well-characterized milk samples, both by veterinary diagnosis and by content of the acute stress biomarker haptoglobin, was analyzed by mass spectrometry and artificial intelligence. Two lipid species (sphingomyelin and phosphatidylcholine) were identified as potential biomarkers of health status in dairy cows. Both lipids allow for the discrimination of milk from sick animals and also milk from those with stress. Moreover, lipidomics revealed specific lipid profiles depending on the origin of the samples and the degree of freedom of the animals on the farm. These data provide evidence for specific lipid changes in stressed animals and open up the possibility that haptoglobin could also affect lipid metabolism in cow’s milk. Full article
(This article belongs to the Special Issue Natural Molecules Controlling Lipid Metabolism)
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16 pages, 3242 KiB  
Article
Pasteurized Akkermansia muciniphila Reduces Fat Accumulation via nhr-49-Mediated Nuclear Hormone Signaling Pathway in Caenorhabditis elegans
by Zhongqin Wu, Yu Xiao, Fang Zhou, Jiaxu Chen, Xinming Chen, Aixiang Hou, Yuanliang Wang and Zongjun Li
Molecules 2022, 27(19), 6159; https://doi.org/10.3390/molecules27196159 - 20 Sep 2022
Cited by 11 | Viewed by 3065
Abstract
Pasteurized Akkermansia muciniphila (p-AKK) is related to lipid metabolism and helps control obesity. The main goal of this study was to investigate the role and mechanism of p-AKK in lipid metabolism using Caenorhabditis elegans. The results showed that p-AKK increased the healthy [...] Read more.
Pasteurized Akkermansia muciniphila (p-AKK) is related to lipid metabolism and helps control obesity. The main goal of this study was to investigate the role and mechanism of p-AKK in lipid metabolism using Caenorhabditis elegans. The results showed that p-AKK increased the healthy lifespan of nematodes and helped maintain exercise ability in aging, suggesting a potential increase in energy expenditure. The overall fat deposition and triglyceride level were significantly decreased and the p-AKK anti-oxidative stress helped to regulate fatty acid composition. Additionally, the transcriptome results showed that p-AKK increased the expression of lipo-hydrolase and fatty acid β-oxidation-related genes, including lipl-4, nhr-49, acs-2 and acdh-8, while it decreased the expression of fat synthesis-related genes, including fat-7, elo-2 and men-1. These results partially explain the mechanisms underlying the fact that p-AKK decreases fat accumulation of C. elegans via nhr-49/acs-2-mediated signaling involved in fatty acid β-oxidation and synthesis. Full article
(This article belongs to the Special Issue Natural Molecules Controlling Lipid Metabolism)
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14 pages, 2056 KiB  
Article
Mitochondrial Aldehyde Dehydrogenase 2 Represents a Potential Biomarker of Biochemical Recurrence in Prostate Cancer Patients
by Dechao Feng, Weizhen Zhu, Jia You, Xu Shi, Ping Han, Wuran Wei, Qiang Wei and Lu Yang
Molecules 2022, 27(18), 6000; https://doi.org/10.3390/molecules27186000 - 15 Sep 2022
Cited by 5 | Viewed by 2351
Abstract
Background: We aimed to explore the role of mitochondrial aldehyde dehydrogenase 2 (ALDH2) in prostate cancer (PCa) patients and provide insights into the tumor immune microenvironment (TME) for those patients undergoing radical radiotherapy. Methods: We performed all analyses using R version 3.6.3 and [...] Read more.
Background: We aimed to explore the role of mitochondrial aldehyde dehydrogenase 2 (ALDH2) in prostate cancer (PCa) patients and provide insights into the tumor immune microenvironment (TME) for those patients undergoing radical radiotherapy. Methods: We performed all analyses using R version 3.6.3 and its suitable packages. Cytoscape 3.8.2 was used to establish network of competing endogenous RNAs (ceRNAs). Results: Downregulation of ADLH2 was significantly associated with higher risk of BCR-free survival (HR: 0.40, 95%CI: 0.24–0.68, p = 0.001) and metastasis-free survival (HR: 0.21, 95%CI: 0.09–0.49, p = 0.002). Additionally, ALDH2 repression contributed to significantly shorter BCR-free survival in the TCGA database (HR: 0.55, 95%CI: 0.33–0.93, p = 0.027). For immune checkpoints, patients that expressed a higher level of CD96 had a higher risk of BCR than their counterparts (HR: 1.79, 95%CI: 1.06–3.03, p = 0.032), as well as NRP1 (HR: 2.18, 95%CI: 1.29–3.69, p = 0.005). In terms of the TME parameters, the spearman analysis showed that ALDH was positively associated with B cells (r: 0.13), CD8+ T cells (r: 0.19), neutrophils (r: 0.13), and macrophages (r: 0.17). Patients with higher score of neutrophils (HR: 1.75, 95%CI: 1.03–2.95, p = 0.038), immune score (HR: 1.92, 95%CI: 1.14–3.25, p = 0.017), stromal score (HR: 2.52, 95%CI: 1.49–4.26, p = 0.001), and estimate score (HR: 1.81, 95%CI: 1.07–3.06, p = 0.028) had higher risk of BCR than their counterparts. Our ceRNA network found that PART1 might regulate the expression of ALDH via has-miR-578 and has-miR-6833-3p. Besides, PHA-793887, PI-103, and piperlongumine had better correlations with ALDH2. Conclusions: We found that ALDH2 might serve as a potential biomarker predicting biochemical recurrence for PCa patients. Full article
(This article belongs to the Special Issue Natural Molecules Controlling Lipid Metabolism)
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Review

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20 pages, 4113 KiB  
Review
Important Hormones Regulating Lipid Metabolism
by Dengke Zhang, Yanghui Wei, Qingnan Huang, Yong Chen, Kai Zeng, Weiqin Yang, Juan Chen and Jiawei Chen
Molecules 2022, 27(20), 7052; https://doi.org/10.3390/molecules27207052 - 19 Oct 2022
Cited by 57 | Viewed by 15041
Abstract
There is a wide variety of kinds of lipids, and complex structures which determine the diversity and complexity of their functions. With the basic characteristic of water insolubility, lipid molecules are independent of the genetic information composed by genes to proteins, which determine [...] Read more.
There is a wide variety of kinds of lipids, and complex structures which determine the diversity and complexity of their functions. With the basic characteristic of water insolubility, lipid molecules are independent of the genetic information composed by genes to proteins, which determine the particularity of lipids in the human body, with water as the basic environment and genes to proteins as the genetic system. In this review, we have summarized the current landscape on hormone regulation of lipid metabolism. After the well-studied PI3K-AKT pathway, insulin affects fat synthesis by controlling the activity and production of various transcription factors. New mechanisms of thyroid hormone regulation are discussed, receptor α and β may mediate different procedures, the effect of thyroid hormone on mitochondria provides a new insight for hormones regulating lipid metabolism. Physiological concentration of adrenaline induces the expression of extrapituitary prolactin in adipose tissue macrophages, which promotes fat weight loss. Manipulation of hormonal action has the potential to offer a new therapeutic horizon for the global burden of obesity and its associated complications such as morbidity and mortality. Full article
(This article belongs to the Special Issue Natural Molecules Controlling Lipid Metabolism)
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