Special Issue "Occurrence and Biological Role of Non-Canonical Structural Motifs in Nucleic Acids"
Deadline for manuscript submissions: closed (30 August 2020).
Interests: DNA; non-canonical nucleic acids motifs; G-quadruplex; cruciform; i-Motif; DNA–ligand interaction; thermodynamic stability; temperature-gradient gel electrophoresis; circular dichroism; aptamers; bio–nano conjugates
It is known that non-canonical structural motifs can be formed under physiological conditions in regions of biological significance. In recent years, G-quadruplexes have received a greatly elevated amount of research interest. G-quadruplex putative sequences are located in telomeres, oncogene promoter regions, replication initiation sites, and untranslated RNA regions (UTR). In addition, a G-quadruplex motif has been found in many newly discovered aptamers. Hairpin-like structures and cruciforms occur in non-coding regions, mainly in promoters of many important genes. Currently, there is a scientific discussion going on about the biological significance of i-motifs in cellular systems. Frequently, non-canonical motifs are found to be associated with many genetic disorders and various cancers. Therefore, non-canonical nucleic acid structures are attractive molecular targets. G-quadruplex interactive ligands have been identified to exhibit antiproliferative activity against tumor models both in vitro and in vivo. This Special Issue aims to provide an opportunity to share new findings and recent advances in non-canonical nucleic acid motifs occurring in various organisms, including viruses and their specific ligands, toward the development of new therapeutically effective drugs against various human health problems.
Assoc. Prof. Dr. Viktor Viglasky
Manuscript Submission Information
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- non-canonical structures in nucleic acids
- nucleic acid conformation and stability
- molecular targets
- targeted ligands