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Special Issue "Occurrence and Biological Role of Non-Canonical Structural Motifs in Nucleic Acids"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (30 August 2020).

Special Issue Editor

Assoc. Prof. Dr. Viktor Viglasky
Guest Editor
Department of Biochemistry, Institute of Chemistry, Faculty of Sciences, P. J. Safarik University, 04001, Kosice, Slovakia
Interests: DNA; non-canonical nucleic acids motifs; G-quadruplex; cruciform; i-Motif; DNA–ligand interaction; thermodynamic stability; temperature-gradient gel electrophoresis; circular dichroism; aptamers; bio–nano conjugates

Special Issue Information

Dear Colleagues,

It is known that non-canonical structural motifs can be formed under physiological conditions in regions of biological significance. In recent years, G-quadruplexes have received a greatly elevated amount of research interest. G-quadruplex putative sequences are located in telomeres, oncogene promoter regions, replication initiation sites, and untranslated RNA regions (UTR). In addition, a G-quadruplex motif has been found in many newly discovered aptamers. Hairpin-like structures and cruciforms occur in non-coding regions, mainly in promoters of many important genes. Currently, there is a scientific discussion going on about the biological significance of i-motifs in cellular systems. Frequently, non-canonical motifs are found to be associated with many genetic disorders and various cancers. Therefore, non-canonical nucleic acid structures are attractive molecular targets. G-quadruplex interactive ligands have been identified to exhibit antiproliferative activity against tumor models both in vitro and in vivo. This Special Issue aims to provide an opportunity to share new findings and recent advances in non-canonical nucleic acid motifs occurring in various organisms, including viruses and their specific ligands, toward the development of new therapeutically effective drugs against various human health problems.

Assoc. Prof. Dr. Viktor Viglasky
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • non-canonical structures in nucleic acids
  • nucleic acid conformation and stability
  • molecular targets
  • targeted ligands
  • viruses
  • bacteria
  • microorganisms
  • aptamers

Published Papers

There is no accepted submissions to this special issue at this moment.
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