Structure, Characterization, and Application of G-Quadruplexes
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Macromolecular Chemistry".
Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 388
Special Issue Editor
Interests: occurrence of non-canonical structures of nucleic acids in living organisms and viruses; cruciform; i-Motif; DNA-ligand interaction; thermodynamic stability; temperature-gradient gel electrophoresis; circular dichroism; aptamers; bio-nano conjugates; biological role of alternative structure
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
G-quadruplexes are a non-canonical structural motif. G-quadruplex putative sequences are located in telomeres, oncogene promoter regions, replication initiation sites, and in untranslated RNA regions. It is generally accepted that non-canonical structural motifs of nucleic acids adopted under physiological conditions in cellular systems can modulate its features. In recent years, G-quadruplexes have received greatly elevated research interest. In addition, the G-quadruplex motif has been found in many newly discovered aptamers. Hairpin-like structures and cruciform occur again in non-coding regions, mainly in promoters of many important genes. Currently there is a scientific discussion going on about the biological significance of the i-motif in cellular systems. Frequently, non-canonical motifs are found to be associated with many genetic disorders and various cancers. Therefore, non-canonical nucleic acid structures are attractive molecular targets. G-quadruplex interactive ligands have been identified to exhibit antiproliferative against tumor models both in vitro and in vivo. This Special Issue aims to provide opportunity to share new findings and recent advances of G-quadruplexes occurring in various organisms, including viruses, and their specific ligands toward the development of new therapeutically effective drugs against various human health problems.
Assoc. Prof. Dr. Viktor Viglasky
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Non-canonical structures in nucleic acids
- Nucleic acids conformation and stability
- Molecular targets
- Targeted ligands
- Viruses
- Bacteria
- Microorganisms
- Aptamers
