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Special Issue "Neuropeptides Involved in Pain Control"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 15 October 2019

Special Issue Editors

Guest Editor
Prof. Dr. Adriano Mollica

University of G. d'Annunzio Chieti and Pescara, Chieti, Italy
Website | E-Mail
Interests: medicinal chemistry; neuropeptides; opioids; SNC; molecular modeling
Guest Editor
Dr. Azzurra Stefanucci

University of G. d'Annunzio Chieti and Pescara, Department of Pharmacy, Chieti, Italy
Website | E-Mail
Interests: peptide synthesis; biphalin; pain; binding assay; G protein receptors

Special Issue Information

Dear Colleagues,

Neuropeptides are well-defined chemical molecules, produced and released by the central nervous system and peripheral. They are involved in the transmission, modulation, and perception of physiological, neuropathic, and inflammatory pain. The development of novel nonpeptide agonists/antagonists, molecular cloning techniques, and transgenic animal models helps to define their functions in the nociceptive cascade, revealing a complex pattern of molecular mechanisms. Often, they are co-localized with neurotransmitters at the same nerve ending, blocking or enhancing their effects. For example, the calcitonin-gene-related peptide (CGRP) and neuropeptide tyrosine (NPY) are expressed and released from non-neuronal cells, acting via the same receptors as their neuronal counterparts. Peptides are endowed with a pleiotropic function, which is responsible for their plasticity under normal and experimental conditions, and redundancy, which may account for the poor performance of individual neuropeptide inhibitors in clinical trials. Accordingly, this Special Issue is focused on the design, synthesis, and biological evaluation of novel neuropeptides with the hope to replace or, at least, complement the use of opiate drugs, leading to increased efficacy and reduced adverse effects.

Prof. Adriano Mollica
Dr. Azzurra Stefanucci
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Neuropeptides
  • Pain
  • Opioid system
  • Cannabinoids
  • Peptide synthesis
  • Peptidomimetics
  • Peptide application
  • Peptide cell-targeting
  • Peptide design

Published Papers

This special issue is now open for submission.
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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