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Special Issue "Investigation of the Molecular Interactions of Natural Products"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 30 September 2019

Special Issue Editor

Guest Editor
Prof. Dr. Lothar Brecker

University of Vienna, Department of Organic Chemistry, Vienna, Austria
Website | E-Mail
Interests: enzyme catalysis; molecular interaction; NMR; organic chemistry; structure determination

Special Issue Information

Dear Colleagues,

Molecular interactions between natural products lead to the formation of molecular complexes, which often show entirely changed physical and chemical properties compared to the free molecules. Hence, in nature, such complexes play an important role in regulating the bioavailability of different compounds in various fields, such as defense on a molecular level or regulation of reproduction. Additionally, molecular interactions between natural products have been used by humans in traditional and modern pharmaceutical applications as well as in plant protection, as a mean to modulate the bioavailability of active agents.

The investigation of molecular complexes and of the details of their molecular interactions require the determination of complexes’ stoichiometry, their various binding properties, and their three-dimensional structures. For this purpose, diverse spectroscopic, spectrometric, and wet chemical analyses are required.

Considering these premises, the present Special Issue aims to collect contributions investigating complexes of natural products with respect to their properties, structures, and biological role in the natural environment, for example, in Phytochemistry or in Chemistry of Marine Natural Products. Furthermore, reports on all applications of molecular complexes which derive from natural products are welcome.

Prof. Dr. Lothar Brecker
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • molecular interactions between natural products
  • bioavailability of natural product complexes
  • stoichiometry, binding properties, and 3D structures of natural product complexes
  • biological role of molecular interactions between natural products
  • applications of natural product complexes

Published Papers (1 paper)

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Research

Open AccessArticle
Pharmacodynamics of Five Anthraquinones (Aloe-emodin, Emodin, Rhein, Chysophanol, and Physcion) and Reciprocal Pharmacokinetic Interaction in Rats with Cerebral Ischemia
Molecules 2019, 24(10), 1898; https://doi.org/10.3390/molecules24101898
Received: 7 April 2019 / Revised: 6 May 2019 / Accepted: 14 May 2019 / Published: 17 May 2019
PDF Full-text (961 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
(1) Background: Rhubarb anthraquinones—a class of components with neuroprotective function—can be used to alleviate cerebral ischemia reperfusion injury. (2) Methods: The three pharmacodynamic indicators are neurological function score, brain water content, and cerebral infarction area; UPLC-MS/MS was used in pharmacokinetic studies to detect [...] Read more.
(1) Background: Rhubarb anthraquinones—a class of components with neuroprotective function—can be used to alleviate cerebral ischemia reperfusion injury. (2) Methods: The three pharmacodynamic indicators are neurological function score, brain water content, and cerebral infarction area; UPLC-MS/MS was used in pharmacokinetic studies to detect plasma concentrations at different time points, and DAS software was used to calculate pharmacokinetic parameters in a noncompartmental model. (3) Results: The results showed that the pharmacodynamics and pharmacokinetics of one of the five anthraquinone aglycones could be modified by the other four anthraquinones, and the degree of interaction between different anthraquinones was different. The chrysophanol group showed the greatest reduction in pharmacodynamic indicators comparing with other four groups where the rats were administered one of the five anthraquinones, and there was no significant difference between the nimodipine group. While the Aloe-emodin + Physcion group showed the most obvious anti-ischemic effect among the groups where the subjects were administered two of the five anthraquinones simultaneously. Emodin, rhein, chrysophanol, and physcion all increase plasma exposure levels of aloe-emodin, while aloe-emodin lower their plasma exposure levels. (4) Conclusions: This experiment provides a certain preclinical basis for the study of anthraquinone aglycones against cerebral ischemia and a theoretical basis for the study of the mechanism of interaction between anthraquinones. Full article
(This article belongs to the Special Issue Investigation of the Molecular Interactions of Natural Products)
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