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Chemistry and Biology of Meroterpenoids

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 2926

Special Issue Editors


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Guest Editor
School of Marine Sciences, Sun Yat-Sen University, Zhuhai 519082, China
Interests: marine fungi; marine natural products; fungal meroterpenoids; fungal peptides; marine drug discovery

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Guest Editor
Institutional Center for Shared Technologies and Facilities, South China Botanical Garden, Chinese Academy of Sciences (CAS), Guangzhou 510520, China
Interests: endophytic fungi; bioactive secondary metabolites; structural elucidation; molecular networking analysis; drug discovery

Special Issue Information

Dear Colleagues,

Meroterpenoids are secondary metabolites from mixed terpene-biosynthetic origins. They are ubiquitously produced in the natural environment (including terrestrial and marine sources), from plants, animals, and microorganisms (including fungi and bacteria (actinomycetes)). Many typical bioactive compounds can be assigned to the meroterpenoids, such as plastoquinone, menadione, vitamin E, vinblastine, tetrahydrocannabinol, merochlorin A, and teleocidin B-4. Their intriguing chemical structural diversification and complexity, potential bioactivities, and pharmacological significance make them attractive targets in natural product chemistry, organic synthesis, and biosynthesis. The chemical diversity and therapeutic potential of these meroterpenoids will provide biologists and medicinal chemists with a promising sustainable treasure trove for drug discovery.

The issue is dedicated to the identification of meroterpenoids from plants, animals, and microorganisms; innovative isolation techniques targeting meroterpenoids; pharmacological characterization; and synthesis of meroterpenoids.

Dr. Senhua Chen
Dr. Hanxiang Li
Guest Editors

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Keywords

  • meroterpenoids
  • pharmacological activities
  • structural elucidation
  • secondary metabolites
  • natural products
  • organic synthesis

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Published Papers (1 paper)

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Research

10 pages, 2532 KiB  
Article
Two New Picoline-Derived Meroterpenoids with Anti-Acetylcholinesterase Activity from Ascidian-Derived Fungus Amphichorda felina
by Minghua Jiang, Heng Guo, Qilin Wu, Siwen Yuan and Lan Liu
Molecules 2022, 27(16), 5076; https://doi.org/10.3390/molecules27165076 - 10 Aug 2022
Cited by 6 | Viewed by 2432
Abstract
Amphichoterpenoids D (1) and E (2), two new picoline-derived meroterpenoids with a rare 6/6/6 tricyclic pyrano[3,2-c]pyridinyl-γ-pyranone scaffold, were isolated from the ascidian-derived fungus Amphichorda felina SYSU-MS7908. Their structures, including the absolute configurations, were established by extensive spectroscopic [...] Read more.
Amphichoterpenoids D (1) and E (2), two new picoline-derived meroterpenoids with a rare 6/6/6 tricyclic pyrano[3,2-c]pyridinyl-γ-pyranone scaffold, were isolated from the ascidian-derived fungus Amphichorda felina SYSU-MS7908. Their structures, including the absolute configurations, were established by extensive spectroscopic methods (1D and 2D NMR and high-resolution mass spectrometry) and ECD calculations. Compounds 1 and 2 showed anti-acetylcholinesterase (anti-AChE) activities with IC50 values of 12.5 μM and 11.6 μM, respectively. The binding interactions between 1, 2, and AChE were investigated using molecular docking analyses. Full article
(This article belongs to the Special Issue Chemistry and Biology of Meroterpenoids)
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