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Cyclodextrin-Based Materials: Preparation, Properties, and Applications

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Macromolecular Chemistry".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 1812

Special Issue Editors


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Guest Editor
Faculty of Science and Technology, Nakhon Ratchasima Rajabhat University, Nakhon Ratchasima 30000, Thailand
Interests: cyclodextrin; multilayer; adsorption; functional textile; biomaterials; wastewater treatment

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Guest Editor
Pharmaceutics and Industrial Pharmacy, Chulalongkorn University, Bangkok 10330, Thailand
Interests: cyclodextrin; nanotechnology; drug delivery system; preformulation; pharmaceutical and cosmetic formulation development

Special Issue Information

Dear Colleagues,

Cyclodextrins (CD) are cyclic oligosaccharides composed of six (α-CD), seven (β-CD), or eight (γ-CD) D-glucose units linked by α-1,4-glycosidic bonds which display a well-defined macrocyclic structure with a hydrophobic cavity and a hydrophilic exterior. The exceptional property of this supramolecular molecule offers the encapsulation of organic molecules with a suitable size into the CD cavity by host–guest interaction to form an inclusion complex. CD and their derivatives were elaborated by different types of chemical reaction to obtain soluble or insoluble fractions which could create complexes with target molecules and enhance the specific properties of imprisoned molecules, such as solubility, bioavailability, adsorption property, sustained release, reactivity of intermediate products, and so on. CD-based nanoparticles have attracted interest as they exhibit potential for delivering compounds to targeted sites and for other purposes in various related areas. Thus, the number of potential applications of CD is expected to only grow for both the academic and industrial sectors, which is why this Special Issue on “Cyclodextrin-Based Materials: Preparation, Properties, and Applications ” is proposed to focus on emerging, innovative materials containing CD with specific properties toward different applications in material science, nanotechnology, pharmacy, medicine, cosmetic, textile, food agriculture, environment, applied science, and other fields.

Dr. Jatupol Junthip
Dr. Phatsawee Jansook
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cyclodextrins for fundamental and advanced materials
  • cyclodextrins for biomaterials and tissue engineering
  • cyclodextrins for nanotechnology and related fields
  • cyclodextrins for pharmaceutical, cosmetic, and medical applications
  • cyclodextrins for textile applications
  • cyclodextrins for food science, agricultural, and environmental science
  • cyclodextrins for polymer science
  • cyclodextrins for basic science and applied science

Published Papers (1 paper)

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Research

21 pages, 4914 KiB  
Article
Fabrication and Characterization of β-Cyclodextrin/Mosla Chinensis Essential Oil Inclusion Complexes: Experimental Design and Molecular Modeling
by Hong-Ning Liu, Xiao-Xia Jiang, Abid Naeem, Fu-Cai Chen, Lu Wang, Yan-Xia Liu, Zhe Li and Liang-Shan Ming
Molecules 2023, 28(1), 37; https://doi.org/10.3390/molecules28010037 - 21 Dec 2022
Cited by 10 | Viewed by 1512
Abstract
Essential oils (EOs) are primarily isolated from medicinal plants and possess various biological properties. However, their low water solubility and volatility substantially limit their application potential. Therefore, the aim of the current study was to improve the solubility and stability of the Mosla [...] Read more.
Essential oils (EOs) are primarily isolated from medicinal plants and possess various biological properties. However, their low water solubility and volatility substantially limit their application potential. Therefore, the aim of the current study was to improve the solubility and stability of the Mosla Chinensis (M. Chinensis) EO by forming an inclusion complex (IC) with β-cyclodextrin (β-CD). Furthermore, the IC formation process was investigated using experimental techniques and molecular modeling. The major components of M. Chinensis ‘Jiangxiangru’ EOs were carvacrol, thymol, o-cymene, and terpinene, and its IC with β-CD were prepared using the ultrasonication method. Multivariable optimization was studied using a Plackett-Burman design (step 1, identifying key parameters) followed by a central composite design for optimization of the parameters (step 2, optimizing the key parameters). SEM, FT-IR, TGA, and dissolution experiments were performed to analyze the physicochemical properties of the ICs. In addition, the interaction between EO and β-CD was further investigated using phase solubility, molecular docking, and molecular simulation studies. The results showed that the optimal encapsulation efficiency and loading capacity of EO in the ICs were 86.17% and 8.92%, respectively. Results of physicochemical properties were different after being encapsulated, indicating that the ICs had been successfully fabricated. Additionally, molecular docking and dynamics simulation showed that β-CD could encapsulate the EO component (carvacrol) via noncovalent interactions. In conclusion, a comprehensive methodology was developed for determining key parameters under multivariate conditions by utilizing two-step optimization experiments to obtain ICs of EO with β-CD. Furthermore, molecular modeling was used to study the mechanisms involved in molecular inclusion complexation. Full article
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