Exploration of Homocysteine Metabolism in Cancer and Petechial Therapeutic Targets
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Chemical Biology".
Deadline for manuscript submissions: closed (31 July 2022) | Viewed by 4125
Special Issue Editors
Interests: HER3; SynNotch CAR-T cell therapy; HER2-positive breast tumors
Special Issues, Collections and Topics in MDPI journals
Interests: autoimmune diseases; cancer; neurological diseases; pshychiatric diseases; reactive oxygen species; reactive nitrogen species; nitric oxide; hydrogen suflide; carbon monoxide; heme oxygenase
Special Issue Information
Dear Colleagues,
Homocysteine (Hcy) is a non-essential amino acid that is produced through the one-carbon metabolism pathway. This is the only pathway that supplies methyl groups to DNA, RNA, and proteins. One-carbon metabolism via the methionine cycle is essential during nucleotide synthesis, methylation, and reductive metabolism, and this pathway supports the high proliferative rate of cancer cells. In the last two decades, several studies have shown that disruption of this pathway is linked to different systemic diseases, such as cardiovascular disorder, neurodegenerative diseases, type 2 diabetes, etc. However, very few studies have been carried out that show that increased plasma Hcy has also been closely related to cancer. Cancer cells require a constant supply of methionine from external sources (also known as the Hoffman effect), suggesting that possibly cancer cells need increased demand for metabolites derived from the one-carbon metabolism pathway. To understand this fact, we need to decode the metabolites that are generated from this one-carbon metabolism cycle.
We invite researchers to contribute to this Special Issue who are working on the generation and usage of one-carbon units in cancer. Original research articles or review articles on the innovative aspect of the exploration of possible future therapeutics that could exploit the dependency of cancer cells on one-carbon metabolism are welcome.
Dr. Avisek Majumder
Prof. Dr. Ferdinando Nicoletti
Guest Editors
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Keywords
- hyperhomocysteinemia
- cancer
- one carbon metabolism
- homocysteine
- cancer therapeutics
- cancer metabolism
- methionine cycle
- methylation
- epigenetics
- methyl group donor
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