Special Issue "Fragment Based Drug Discovery"
Deadline for manuscript submissions: closed (30 November 2019).
Interests: fragment-based drug discovery; 1H and 19F NMR-based activity assays; Nucleoside ribohydrolase inhibitors as novel antitrichomonal agents
Fragment-based drug discovery has become widespread in industry and academia. The utility of the approach has been validated by the steadily increasing number of compounds in the clinic that were developed from hits having their origins in fragment screens. The approach continues to be improved by refinements in fragment library design, development of new and often complementary screening methods, and more efficient transitions from fragment hits to structure-guided medicinal chemistry. This Special Issue will disseminate advances in fragment library design and screening methodologies, along with recent applications of fragment-based ligandability assessment and drug discovery to novel pharmaceutical targets.
Prof. Dr. Brian J. Stockman
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Fragment library design
- Fragment screening
- Hit-to-lead transition
- Molecular modeling
- NMR spectroscopy
- X-ray crystallography
- Surface plasmon resonance
- Target ligandability
- Protein-protein interaction inhibitors
- Enzyme inhibitors