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Special Issue "Fragment Based Drug Discovery"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 31 August 2019

Special Issue Editor

Guest Editor
Prof. Dr. Brian J. Stockman

Department of Chemistry, Adelphi University, Garden City, New York, USA
Website | E-Mail
Interests: fragment-based drug discovery; 1H and 19F NMR-based activity assays; Nucleoside ribohydrolase inhibitors as novel antitrichomonal agents

Special Issue Information

Dear Colleagues,

Fragment-based drug discovery has become widespread in industry and academia. The utility of the approach has been validated by the steadily increasing number of compounds in the clinic that were developed from hits having their origins in fragment screens. The approach continues to be improved by refinements in fragment library design, development of new and often complementary screening methods, and more efficient transitions from fragment hits to structure-guided medicinal chemistry. This Special Issue will disseminate advances in fragment library design and screening methodologies, along with recent applications of fragment-based ligandability assessment and drug discovery to novel pharmaceutical targets.

Prof. Dr. Brian J. Stockman
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Fragment library design
  • Fragment screening
  • Hit-to-lead transition
  • Molecular modeling
  • NMR spectroscopy
  • X-ray crystallography
  • Surface plasmon resonance
  • Target ligandability
  • Protein-protein interaction inhibitors
  • Enzyme inhibitors

Published Papers

This special issue is now open for submission.
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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