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New Strategies and Drugs Against Intracellular Pathogens

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 3102

Special Issue Editors

Institute of Translational Medicine, School of Medicine, Yangzhou University, Yangzhou 225009, China
Interests: parasite; protein; antimalarial drugs
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou 225001, China
Interests: toxoplasmosis; natural products; drugs; immunity

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Guest Editor
Department of Medical Environmental Biology and Tropical Medicine, School of Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea
Interests: malaria; hematology; antigen; antibody; vaccine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The infectious diseases, such as Mycobacterium tuberculosis, Plasmodium falciparum and human immunodeficiency virus, caused by intracellular pathogens pose the most profound impact on public health. Despite being caused by different organisms, the intracellular infectious diseases present a series of challenges in emergency, infection persistence, and drug resistance, highlighting the urgent need for new and deeper insights into surveillance, pathobiology of these diverse invaders and disease interventions. To face these challenges, new methods or drugs that facilitate the efficient treatment and prevention of the pathogens are required continually.

The Special Issue “New Strategies and Drugs Against Intracellular Pathogens” aims to present the most recent achievements in drug screen, drug sensitivity and resistance mechanisms, especially new compounds such as Natural product molecules or new inhibitors, which predict important advances in treatment of diseases caused by intracellular pathogens. Manuscripts, together with review papers, will summarize the “state of the art” of the strategies and drugs of intracellular pathogens.

Dr. Feng Lu
Dr. Siyang Huang
Dr. Jin Hee Han
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • intracellular pathogen
  • method
  • drug
  • drug screen
  • drug sensitivity
  • resistance
  • natural product

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Published Papers (1 paper)

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Research

17 pages, 2968 KiB  
Article
Four Chemotherapeutic Compounds That Limit Blood-Brain-Barrier Invasion by Toxoplasma gondii
by Zijing Yan, Hao Yuan, Junjie Wang, Zipeng Yang, Pian Zhang, Yasser S. Mahmmod, Xiaohu Wang, Tanghui Liu, Yining Song, Zhaowen Ren, Xiu-Xiang Zhang and Zi-Guo Yuan
Molecules 2022, 27(17), 5572; https://doi.org/10.3390/molecules27175572 - 30 Aug 2022
Cited by 3 | Viewed by 2254
Abstract
Background: Toxoplasma gondii, an intracellular protozoan parasite, exists in the host brain as cysts, which can result in Toxoplasmic Encephalitis (TE) and neurological diseases. However, few studies have been conducted on TE, particularly on how to prevent it. Previous proteomics studies have [...] Read more.
Background: Toxoplasma gondii, an intracellular protozoan parasite, exists in the host brain as cysts, which can result in Toxoplasmic Encephalitis (TE) and neurological diseases. However, few studies have been conducted on TE, particularly on how to prevent it. Previous proteomics studies have showed that the expression of C3 in rat brains was up-regulated after T. gondii infection. Methods: In this study, we used T. gondii to infect mice and bEnd 3 cells to confirm the relation between T. gondii and the expression of C3. BEnd3 cells membrane proteins which directly interacted with C3a were screened by pull down. Finally, animal behavior experiments were conducted to compare the differences in the inhibitory ability of TE by four chemotherapeutic compounds (SB290157, CVF, NSC23766, and Anxa1). Results: All chemotherapeutic compounds in this study can inhibit TE and cognitive behavior in the host. However, Anxa 1 is the most suitable material to inhibit mice TE. Conclusion: T. gondii infection promotes TE by promoting host C3 production. Anxa1 was selected as the most appropriate material to prevent TE among four chemotherapeutic compounds closely related to C3. Full article
(This article belongs to the Special Issue New Strategies and Drugs Against Intracellular Pathogens)
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