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Chemistry and Applications of Group 7 Metal Complexes

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organometallic Chemistry".

Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 10635

Special Issue Editor


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Guest Editor
Department of Chemistry, University of Fribourg, CH-1700 Fribourg, Switzerland
Interests: rhenium; CORMs; bio-inspired materials; anticancer agents; antimicrobial agents; drug design

Special Issue Information

Dear Colleagues,

Metal complexes of the group 7 are investigated for their use as catalysts, imaging probes, radiopharmaceuticals, photosensitizers in photocatalysis, for their potential as antitumor and antimicrobial agents, and other medical applications. The main aim of the Special Issue on “Chemistry and Applications of Group 7 Metal Complexes” is to be an open forum where researchers may share their latest investigations and findings in these exciting fields of research. Thanks to the open access platform, the community will benefit from increased visibility and the chances to strengthen its scientific bonds as well as contributing to the global shift to an Open Science for all. Contributions to this issue, both in the form of original research or review articles, may cover all aspects of pure and applied chemistry of group 7 metal complexes; studies with multidisciplinary input, offering new methodologies or insights, are particularly welcome.

Prof. Dr. Fabio Zobi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Manganese
  • Technetium
  • Rhenium
  • CO releasing molecules
  • Biomedical applications
  • Drug design
  • Imaging
  • Catalysis

Published Papers (3 papers)

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Research

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19 pages, 3048 KiB  
Article
Efficient Direct Nitrosylation of α-Diimine Rhenium Tricarbonyl Complexes to Structurally Nearly Identical Higher Charge Congeners Activable towards Photo-CO Release
by Sara Nasiri Sovari, Isabelle Kolly, Kevin Schindler, Youri Cortat, Shing-Chi Liu, Aurelien Crochet, Aleksandar Pavic and Fabio Zobi
Molecules 2021, 26(17), 5302; https://doi.org/10.3390/molecules26175302 - 31 Aug 2021
Cited by 3 | Viewed by 3055
Abstract
The reaction of rhenium α-diimine (N-N) tricarbonyl complexes with nitrosonium tetrafluoroborate yields the corresponding dicarbonyl-nitrosyl [Re(CO)2(NO)(N-N)X]+ species (where X = halide). The complexes, accessible in a single step in good yield, are structurally nearly identical higher charge congeners of the [...] Read more.
The reaction of rhenium α-diimine (N-N) tricarbonyl complexes with nitrosonium tetrafluoroborate yields the corresponding dicarbonyl-nitrosyl [Re(CO)2(NO)(N-N)X]+ species (where X = halide). The complexes, accessible in a single step in good yield, are structurally nearly identical higher charge congeners of the tricarbonyl molecules. Substitution chemistry aimed at the realization of equivalent dicationic species (intended for applications as potential antimicrobial agents), revealed that the reactivity of metal ion in [Re(CO)2(NO)(N-N)X]+ is that of a hard Re acid, probably due to the stronger π-acceptor properties of NO+ as compared to those of CO. The metal ion thus shows great affinity for π-basic ligands, which are consequently difficult to replace by, e.g., σ-donor or weak π-acids like pyridine. Attempts of direct nitrosylation of α-diimine fac-[Re(CO)3]+ complexes bearing π-basic OR-type ligands gave the [Re(CO)2(NO)(N-N)(BF4)][BF4] salt as the only product in good yield, featuring a stable Re-FBF3 bond. The solid state crystal structure of nearly all molecules presented could be elucidated. A fundamental consequence of the chemistry of [Re(CO)2(NO)(N-N)X]+ complexes, it that the same can be photo-activated towards CO release and represent an entirely new class of photoCORMs. Full article
(This article belongs to the Special Issue Chemistry and Applications of Group 7 Metal Complexes)
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15 pages, 1403 KiB  
Article
Sorbitol as a Polar Pharmacological Modifier to Enhance the Hydrophilicity of 99mTc-Tricarbonyl-Based Radiopharmaceuticals
by Carolina Giammei, Theresa Balber, Katarina Benčurová, Jens Cardinale, Neydher Berroterán-Infante, Marie Brandt, Nedra Jouini, Marcus Hacker, Markus Mitterhauser and Thomas L. Mindt
Molecules 2020, 25(11), 2680; https://doi.org/10.3390/molecules25112680 - 9 Jun 2020
Cited by 2 | Viewed by 3149
Abstract
The organometallic technetium-99m tricarbonyl core, [99mTc][Tc(CO)3(H2O)3]+, is a versatile precursor for the development of radiotracers for single photon emission computed tomography (SPECT). A drawback of the 99mTc-tricarbonyl core is its lipophilicity, which [...] Read more.
The organometallic technetium-99m tricarbonyl core, [99mTc][Tc(CO)3(H2O)3]+, is a versatile precursor for the development of radiotracers for single photon emission computed tomography (SPECT). A drawback of the 99mTc-tricarbonyl core is its lipophilicity, which can influence the pharmacokinetic properties of the SPECT imaging probe. Addition of polar pharmacological modifiers to 99mTc-tricarbonyl conjugates holds the promise to counteract this effect and provide tumor-targeting radiopharmaceuticals with improved hydrophilicities, e.g., resulting in a favorable fast renal excretion in vivo. We applied the “Click-to-Chelate” strategy for the assembly of a novel 99mTc-tricarbonyl labeled conjugate made of the tumor-targeting, modified bombesin binding sequence [Nle14]BBN(7–14) and the carbohydrate sorbitol as a polar modifier. The 99mTc-radiopeptide was evaluated in vitro with PC-3 cells and in Fox-1nu mice bearing PC-3 xenografts including a direct comparison with a reference conjugate lacking the sorbitol moiety. The glycated 99mTc-tricarbonyl peptide conjugate exhibited an increased hydrophilicity as well as a retained affinity toward the Gastrin releasing peptide receptor and cell internalization properties. However, there was no significant difference in vivo in terms of pharmacokinetic properties. In particular, the rate and route of excretion was unaltered in comparison to the more lipophilic reference compound. This could be attributed to the intrinsic properties of the peptide and/or its metabolites. We report a novel glycated (sorbitol-containing) alkyne substrate for the “Click-to-Chelate” methodology, which is potentially of general applicability for the development of 99mTc-tricarbonyl based radiotracers displaying an enhanced hydrophilicity. Full article
(This article belongs to the Special Issue Chemistry and Applications of Group 7 Metal Complexes)
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Review

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25 pages, 5151 KiB  
Review
Anticancer and Antibiotic Rhenium Tri- and Dicarbonyl Complexes: Current Research and Future Perspectives
by Kevin Schindler and Fabio Zobi
Molecules 2022, 27(2), 539; https://doi.org/10.3390/molecules27020539 - 15 Jan 2022
Cited by 33 | Viewed by 3716
Abstract
Organometallic compounds are increasingly recognized as promising anticancer and antibiotic drug candidates. Among the transition metal ions investigated for these purposes, rhenium occupies a special role. Its tri- and dicarbonyl complexes, in particular, attract continuous attention due to their relative ease of preparation, [...] Read more.
Organometallic compounds are increasingly recognized as promising anticancer and antibiotic drug candidates. Among the transition metal ions investigated for these purposes, rhenium occupies a special role. Its tri- and dicarbonyl complexes, in particular, attract continuous attention due to their relative ease of preparation, stability and unique photophysical and luminescent properties that allow the combination of diagnostic and therapeutic purposes, thereby permitting, e.g., molecules to be tracked within cells. In this review, we discuss the anticancer and antibiotic properties of rhenium tri- and dicarbonyl complexes described in the last seven years, mainly in terms of their structural variations and in vitro efficacy. Given the abundant literature available, the focus is initially directed on tricarbonyl complexes of rhenium. Dicarbonyl species of the metal ion, which are slowly gaining momentum, are discussed in the second part in terms of future perspective for the possible developments in the field. Full article
(This article belongs to the Special Issue Chemistry and Applications of Group 7 Metal Complexes)
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