Complexes as Tool for Design and Synthesis of Species with Biological Application

Dear Colleagues,

The evolution of diseases in the last few decades has necessitated both the diversification and improvement of treatment approaches. For example, bacterial infections are becoming increasingly resistant to antibiotics or difficult to treat due to complications arising from biofilm formation. On the other hand, antitumor agents currently used in cancer treatment are expensive, induce toxicity and resistance, and are ineffective in managing metastasis. Furthermore, there is a lack of drugs for treating conditions such as diabetes mellitus, viral and parasitic infections, and inflammatory diseases. As a result, there is a pressing need for either new drugs or optimized formulations to achieve effective treatment.

To address this, metal complexes and their hybrid-based materials represent promising tools, as their chemical and biological properties can be fine-tuned through the appropriate selection of ligands and/or species that facilitate proper delivery. Consequently, there is continuous interest in designing and testing new metal complexes and hybrid materials by incorporating them into organic or inorganic matrices with valuable biological properties. Additionally, research in this field focuses on identifying suitable administration routes to preserve these properties in vivo.

Dr. Rodica Olar
Guest Editor

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