Special Issue "Bioorthogonal Chemistry"


A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: closed (30 November 2013)

Special Issue Editor

Guest Editor
Dr. Floris van Delft
Institute for Molecules and Materials, Radboud University Nijmegen, Heyendaalseweg 135, NL-6525 AJ Nijmegen, The Netherlands
Website: http://ncmls.nl/people/delft,-van/
E-Mail: F.vanDelft@science.ru.nl
Interests: bioconjugation; copper-free click chemistry; glycopeptides; nucleotide conjugates; oligosaccharide synthesis; small molecule synthesis; catalysis; chemical biology

Special Issue Information

Dear Colleagues.

The recent strategy to apply chemical reactions to address fundamental biological questions has led to the emergence of entirely new conjugation reactions that are fast and irreversible, yet so mild and selective that they can be performed even in or on living cells or in whole organisms. These so-called bioorthogonal reactions, for example the strain-promoted cycloaddition of cyclooctyne with azide or tetrazine, or trans-cyclooctene with tetrazine, open novel avenues, not only in chemical biology research, but also in many other life sciences applications, including the site-specific modification of proteins, in vitro diagnostics, biomaterials, regenerative medicine, imaging and potentially even image-guided surgery. Research papers and reviews dealing with the presented fields are welcome for the preparation of this Special Issue of Molecules.

Dr. Floris van Delft
Guest Editor


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs).


  • bioorthogonal reactions
  • copper-free click
  • strain-promoted cycloaddition
  • in vivo chemistry
  • biomaterial science
  • peptidoglycans
  • glycoproteins
  • nucleotide conjugates
  • site-specific conjugation
  • immobilization

Published Papers (4 papers)

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Displaying article 1-4
p. 2481-2496
by , , , ,  and
Molecules 2014, 19(2), 2481-2496; doi:10.3390/molecules19022481
Received: 30 December 2013 / Revised: 10 February 2014 / Accepted: 12 February 2014 / Published: 21 February 2014
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(This article belongs to the Special Issue Bioorthogonal Chemistry)
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p. 1378-1393
by  and
Molecules 2014, 19(2), 1378-1393; doi:10.3390/molecules19021378
Received: 23 December 2013 / Revised: 9 January 2014 / Accepted: 17 January 2014 / Published: 27 January 2014
Show/Hide Abstract | Cited by 3 | PDF Full-text (390 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Bioorthogonal Chemistry)
p. 1004-1022
by , , ,  and
Molecules 2014, 19(1), 1004-1022; doi:10.3390/molecules19011004
Received: 4 December 2013 / Revised: 7 January 2014 / Accepted: 9 January 2014 / Published: 15 January 2014
Show/Hide Abstract | Cited by 2 | PDF Full-text (735 KB) | HTML Full-text | XML Full-text | Supplementary Files
(This article belongs to the Special Issue Bioorthogonal Chemistry)
abstract graphic
p. 9650-9662
by  and
Molecules 2013, 18(8), 9650-9662; doi:10.3390/molecules18089650
Received: 23 July 2013 / Revised: 1 August 2013 / Accepted: 7 August 2013 / Published: 12 August 2013
Show/Hide Abstract | Cited by 1 | PDF Full-text (612 KB)
(This article belongs to the Special Issue Bioorthogonal Chemistry)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Type of Paper: Review
Title: Chemical Reporters for the Study of Posttranslational Modifica-tions Catalyzed by Native Enzymes
Authors: Ian R. Bothwell 1,2 and Minkui Luo 1,*
Affiliations: 1 Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, United States; E-Mail: bothweli@mskcc.org
2 Tri-Institutional Training Program in Chemical Biology, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, United States; E-Mails: luom@mskcc.org; bothweli@mskcc.org
Abstract: Posttranslational modification of proteins involves the addition or removal of chemical functionalities, which elicits changes in their structure and function. Although these modifications are thought to be a significant source of the biochemical diversity observed in living organisms, their broad study has proven difficult using traditional biochemical techniques. In light of this, much recent advancement in the field of posttranslational modi-fications has relied on the development of bioorthogonal chemistry-based approaches, which utilize the distinct specificity of several chemical reactions to covalently label suita-bly reactive surrogate modifications in complex biological milieu for further study. In this review, we will highlight recent works aimed at the study of several posttranslational mod-ifications using this approach for proteomics or biochemical analysis.

Last update: 13 August 2013

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