Special Issue "Synthesis and Biological Applications of Glycoconjugates Ⅱ"
Deadline for manuscript submissions: closed (1 April 2019)
Prof. Dr. Lothar Elling
Laboratory for Biomaterials, Institute of Biotechnology and Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, Pauwelsstraße 20, 52074 Aachen, Germany
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Interests: glycoconjugates; enzyme cascade reactions; chemo-enzymatic synthesis; glycosyltransferases; nucleotide sugars; galectins; lectins; glycopolymers; biosensors; biomaterials
Glycoconjugates (glycoproteins, glycolipids, proteoglycans) are involved in numerous biological recognition events. Their glycans encode the specific information to trigger protein–glycan interactions. Intercellular crosstalk and pathogen–host interactions are examples and are directly related to the vast chemical diversity of glycan structures. Glycan synthesis via chemical and/or enzymatic approaches are therefore challenging. Novel and efficient procedures for glycan-based products need to be developed and optimized. Multi-enzyme cascade reactions are key for the production of glycans in a larger scale. Protein engineering of enzymes serve to tailor biocatalysts with favorable and novel properties. Most importantly, the combination of chemo- and biocatalysis expands the spectrum of novel synthetic routes. In this way, complex glycans and neo-glycoconjugates will be accessible for biological applications. Multivalency is a key factor for decoding glycan information by carbohydrate recognizing molecules such as lectins and antibodies leading to many applications in biomedicine, biomaterial research, and advanced material sciences. Examples have been seen already in the first Special Issue “Synthesis and Biological Applications of Glycoconjugates” in Molecules in 2017.
I cordially invite you to contribute and share your recent research results in the upcoming second Special Issue on all aspects of the synthesis and biological applications of glycoconjugates.
Prof. Dr. Lothar Elling
Manuscript Submission Information
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- cascade reactions
- chemo-enzymatic synthesis
- glycoconjugates in tissue engineering
- glycoconjugates of the microbiome
- glycoconjugates in host-pathogen interaction
- Synthesis and Biological Applications of Glycoconjugates in Molecules (7 articles)