Special Issue "Bioassay-Guided Isolation of Natural Products"
A special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: closed (28 February 2013) | Viewed by 29837
After suffering a twenty year decline, the field of natural products is currently assuming new prominence. Plants, animals, and microorganisms have always been a continual source of new and useful compounds. Modern analytical and genetic techniques have made it considerably easier to isolate and exploit these compounds for human uses such as antibiotics and pesticides. Bioassay-guided isolation is still the basic procedure for characterizing new natural products with defined biological activity. The most effective assays are rapid and specific. Microorganisms are usually the assay organism that best fits this description especially when attempting to isolate new antibiotics. The basic techniques of agar and broth assays can be enhanced by use of genetically modified test organisms to increase efficiency. Automated assays in microtiter plates allow the testing of large numbers of samples in a short time. Once a target compound has been tentatively identified, metabolomics techniques can be used to find the appropriate strain of producer and optimize production. Equipped with an array of sensitive and rapid assays and analytical methods, the natural product researcher is more prepared than ever to explore nature’s vast frontier of chemical wonders.
Prof. Dr. Florence K. Gleason
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