Special Issue "Bioassay-Guided Isolation of Natural Products"
A special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: closed (28 February 2013).
Interests: anti-bacterial compounds; cyanobacteria; herbicides; lactones; LC-MS; membrane disruptors photosystem II inhibitors; peptides
After suffering a twenty year decline, the field of natural products is currently assuming new prominence. Plants, animals, and microorganisms have always been a continual source of new and useful compounds. Modern analytical and genetic techniques have made it considerably easier to isolate and exploit these compounds for human uses such as antibiotics and pesticides. Bioassay-guided isolation is still the basic procedure for characterizing new natural products with defined biological activity. The most effective assays are rapid and specific. Microorganisms are usually the assay organism that best fits this description especially when attempting to isolate new antibiotics. The basic techniques of agar and broth assays can be enhanced by use of genetically modified test organisms to increase efficiency. Automated assays in microtiter plates allow the testing of large numbers of samples in a short time. Once a target compound has been tentatively identified, metabolomics techniques can be used to find the appropriate strain of producer and optimize production. Equipped with an array of sensitive and rapid assays and analytical methods, the natural product researcher is more prepared than ever to explore nature’s vast frontier of chemical wonders.
Prof. Dr. Florence K. Gleason
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access semimonthly journal published by MDPI.