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Asymmetric Catalysis and Synthesis 2023

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organometallic Chemistry".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 2718

Special Issue Editor


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Guest Editor
Department of Organic Chemistry, Faculty of Science, Beijing University of Chemical Technology, Beijing 100029, China
Interests: synthetic methodology; asymmetric synthesis and catalysis; heterocycles; taurines; peptide chemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Enantiopure organic compounds are important in both biological and medicinal chemistry and material chemistry. Most medicines are optically active compounds. Asymmetric catalysis and synthesis are efficient methods for the preparation of optically active organic compounds and have been well developed over the last three decades. Various optically active chiral catalysts and asymmetric reactions have been achieved and applied.

This Special issue of Molecules welcomes leading scientists to submit original research papers and reviews in the field of asymmetric catalysis and synthesis, including asymmetric synthesis, asymmetric catalysis, transition metal-catalyzed asymmetric catalysis and synthesis, organocatalyzed asymmetric catalysis and synthesis, enzyme-catalyzed catalysis and synthesis, kinetic resolution, theoretical investigations into asymmetric catalysis and synthesis, chemical modification of chiral organic compounds, and the related biological activity. Potential topics include, but are not limited to, the keywords listed below.

Prof. Dr. Jiaxi Xu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • asymmetric synthesis
  • asymmetric catalysis
  • transition metal-catalyzed asymmetric catalysis and synthesis
  • organocatalyzed asymmetric catalysis and synthesis
  • enzyme-catalyzed catalysis and synthesis
  • kinetic resolution
  • theoretical investigations into asymmetric catalysis and synthesis

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Published Papers (1 paper)

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Research

15 pages, 2665 KiB  
Article
Asymmetric 1,4-Michael Addition Reaction of Azadienes with α-Thiocyanoindanones Catalyzed by Bifunctional Chiral Squaramide
by Xiao-Yan Dong and Da-Ming Du
Molecules 2021, 26(17), 5146; https://doi.org/10.3390/molecules26175146 - 25 Aug 2021
Cited by 4 | Viewed by 2007
Abstract
In this paper, the organocatalytic asymmetric 1,4-Michael addition reaction of azadienes and α-thiocyanoindanones was investigated. A series of chiral benzofuran compounds containing thiocyano group and quaternary carbon center were synthesized in moderate yields with good enantioselectivities (up to 90:10 er) and high [...] Read more.
In this paper, the organocatalytic asymmetric 1,4-Michael addition reaction of azadienes and α-thiocyanoindanones was investigated. A series of chiral benzofuran compounds containing thiocyano group and quaternary carbon center were synthesized in moderate yields with good enantioselectivities (up to 90:10 er) and high diastereoselectivities (up to >95:5 dr). This is the first case of 1,4-Michael addition reaction using α-thiocyanoindanones to obtain a series of chiral thiocyano compounds and further broaden the scope of application of azadiene substrates. In addition, a possible reaction mechanism is also described in the article. Full article
(This article belongs to the Special Issue Asymmetric Catalysis and Synthesis 2023)
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