Application of Natural Products in the Treatment of Neurodegenerative Diseases
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 7
Special Issue Editor
Special Issue Information
Dear Colleagues,
Neurovascular and Neurodegenerative Disorders constitute a significant global health challenge with limited treatment options. This special issue examines the therapeutic potential of naturally occurring compounds in addressing chronic neurological disorders pathologies such as Alzheimer’s disease, Parkinson’s disease, and Stroke. Contributions encompass the complete pharmaceutical development continuum: from the isolation and characterization of novel neuroprotective agents derived from terrestrial flora, marine ecosystems, and microbial sources to innovative methodologies for preclinical evaluation, mechanistic investigation, and clinical implementation. Central investigations focus on the role of phytochemicals including but not limited to alkaloids, polyphenols, and terpenoids in mitigating oxidative stress, protein misfolding, neuroinflammatory responses, and mitochondrial dysregulation. The collection also examines advanced strategies for improving bioavailability, developing site-specific delivery mechanisms, and designing combinatorial treatment regimens. Through bridging ethnopharmacological knowledge with multi-omics technologies and translational research frameworks, this compilation seeks to accelerate the creation of effective multitarget neuroprotective interventions while emphasizing the complementary relationship between ancestral wisdom and contemporary pharmacological science.
Dr. Guiyi Gong
Guest Editor
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Keywords
- natural products
- neurovascular and neurodegenerative diseases
- neuroprotection
- bioactive compounds
- drug discovery
- molecular mechanisms
- multi-target therapy
- neuroinflammation
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