Advances in Chemical Biology of Blood Vessels: From Molecular Interactions to Prospective Targets

Dear Colleagues,

The chemical biology of blood vessels investigates the molecular mechanisms driving angiogenesis, vascular permeability, and remodeling. Endothelial cells integrate a myriad of signaling processes to maintain homeostasis. Dysregulation underpins atherosclerosis, tumor angiogenesis, and diabetic vasculopathy. Despite progress using chemoproteomics and activity-based profiling, key gaps persist in defining endothelial heterogeneity, spatiotemporal signaling dynamics, and network crosstalk. Emerging tools, including single-cell multiomics, spatial proteomics, and real-time chemical probes, offer opportunities to address these challenges.

This Special Issue aims to publish recent advances and reviews which critically evaluate unresolved questions, and we seek articles that outline future directions for precision targeting of vascular pathophysiology.

This Special Issue highlights molecular and chemical mechanisms regulating angiogenesis, vascular permeability, and remodeling. Emphasis is placed on endothelial signaling, metabolic and redox control, and innovative tools including chemoproteomics, single-cell multiomics, spatial proteomics, and real-time probes. The Issue addresses endothelial heterogeneity, spatiotemporal signaling, and network crosstalk, guiding future strategies for precision targeting in cardiovascular disease, cancer, and diabetes.

Aligning with the journal’s focus on molecular and chemical biology, the Special Issue emphasizes mechanistic insight, technological innovation, and translational impact, appealing to researchers probing vascular function and developing targeted therapies.

Suggested themes include vascular signaling, metabolism, endothelial heterogeneity, pathophysiology, and chemical biology tools. Article types include original research, reviews, perspectives, and methodological papers.

We look forward to receiving your contributions.

Dr. Anthony Zulli
Guest Editor

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