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Discovery, Isolation, and Mechanisms of Bioactive Natural Products (2nd Edition)

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 651

Special Issue Editor


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Guest Editor
Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China
Interests: omics; natural product; anti-diabetes; neural protection; plant growth regulation; natural product repurposing; alkaloids; limonoids
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Special Issue Information

Dear Colleagues,

We are pleased to announce the Special Issue "Discovery, Isolation, and Mechanisms of Bioactive Natural Products (2nd Edition)". This Special Issue aims to publish research and advances in the field of natural product discovery, particularly in the identification and characterization of bioactive compounds from natural sources and the investigation of their mechanisms of action.

The scope of this Special Issue includes, but is not limited to, the following areas: the isolation, purification, and structural elucidation of natural products; bioassay-guided fractionation; biological evaluation and the active mechanism of natural products; and natural-product-based drug discovery and development.

We welcome contributions from researchers with diverse backgrounds and perspectives and encourage the submission of high-quality manuscripts that advance our understanding of the discovery and mechanistic studies of bioactive natural products. We believe this Special Issue will serve as a valuable resource for the scientific community, and we look forward to receiving your submissions.

Dr. Qiang Zhang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products
  • bioactivities
  • structural elucidation
  • mechanisms

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Published Papers (1 paper)

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Research

23 pages, 11634 KB  
Article
Optimization of the Chitosan-Assisted Extraction for Phillyrin and Forsythoside A from Forsythia suspensa Leaves Using Response Surface Methodology
by Teng Wang, Zexi Zhang, Jiayu Wang, Yuanyuan Fu, Xiaolin Zou, Wei Li, Zhaolun Zhang, Youting Liu, Zhaojun Jia, Zhenguo Wen and Yong Chen
Molecules 2025, 30(17), 3528; https://doi.org/10.3390/molecules30173528 - 29 Aug 2025
Viewed by 447
Abstract
In this study, a green and efficient extraction methodology was developed by leveraging the unique properties of chitosan—namely its non-toxicity, biocompatibility, and adhesive nature—to enhance the recovery of bioactive ingredients from Forsythia suspensa leaves. The core mechanism involves the formation of complexes between [...] Read more.
In this study, a green and efficient extraction methodology was developed by leveraging the unique properties of chitosan—namely its non-toxicity, biocompatibility, and adhesive nature—to enhance the recovery of bioactive ingredients from Forsythia suspensa leaves. The core mechanism involves the formation of complexes between chitosan and the target bioactive ingredients, which significantly boosts their extraction efficiency. To substantiate this mechanism, comprehensive characterization was performed using Powder X-ray Diffraction (PXRD), Fourier Transform Infrared Spectroscopy (FT-IR), Differential Scanning Calorimetry (DSC), Scanning Electron Microscopy (SEM), and molecular docking analyses. The results provided robust evidence of a strong interaction between chitosan and the bioactive ingredients, leading to a marked enhancement in both the stability and aqueous solubility of the target compounds. For process optimization, a multi-objective approach was implemented using the Non-dominated Sorting Genetic Algorithm II (NSGA-II) to simultaneously maximize the extraction yields of phillyrin and forsythoside A. The algorithm identified the optimal parameters as a leaf-to-chitosan mass ratio of 10:11.75, a solid-to-liquid ratio of 1:52 g/mL, a temperature of 80 °C, and a duration of 120 min. Under these optimized conditions, the corresponding extraction yields for phillyrin and forsythoside A were 1.68 ± 0.16% and 3.23 ± 0.27%, respectively. These findings collectively indicate that chitosan-assisted extraction represents a highly promising and advanced technology for the sustainable and effective extraction of bioactive ingredients from botanical sources. Full article
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