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Coordination Complexes of 3d Metals as Anticancer, Antiviral, Antimicrobial, Antifungal...
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Coordination Complexes of 3d Metals as Anticancer, Antiviral, Antimicrobial, Antifungal and Anti-inflammatory Agents

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (31 December 2024) | Viewed by 1700

Special Issue Editors

Prof. Dr. Salah Massoud

E-Mail Website
Guest Editor
Department of Chemistry, University of Louisiana at Lafayette, Lafayette, LA 70504-4370, USA
Interests: coordination chemistry relevant to biological systems, namely DNA cleavage and phosphodiester hydrolysis by mononuclear and polynuclear coordination compounds and anticancer agents based on novel Cu(II) complexes; molecular magnetism, magnetic properties, single-molecule magnets (SMMs) and field-induced single-ion magnets (SIMs); synthesis and characterization of novel mononuclear, polynuclear and coordination polymers (CPs); luminescence emission properties of (n-1)d10 coordination compounds Zn(II) and Cd(II) and lanthanides; carbon dioxide fixation by coordination compounds
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Febee Rophail Y. Louka

E-Mail Website
Guest Editor
Department of Chemistry, University of Louisiana at Lafayette, Lafayette, LA 70504-4370, USA
Interests: synthesis and characterization of novel mononuclear, binuclear and polynuclear coordination compounds based metal(II) complexes and their applications in biological systems; studying the effect of changing the metal and the steric effect on the mechanism of DNA cleavage by metal(II) complexes; investigating the role of the ligand on the efficiency of copper(II) complexes based on different ligands as anticancer agents and studying the cytotoxicity; synthesis and characterization of novel mononuclear, polynuclear and coordination polymers (CPs) and investigate the luminescence emission properties; synthesis of poly-metal complexes for coating micro- and nano- biosensors used in the medicinal field
Dr. Francois Villinger

E-Mail Website
Guest Editor
Department of Biology Director, New Iberia Research Center, University of Louisiana at Lafayette, New Iberia, LA 70560, USA
Interests: therapeutics; immunopathology, vaccine, therapeutics; in vitro models of human diseases

Special Issue Information

Dear Colleagues,

Some of the 3d Metal ions play crucial roles not only as essential elements for life but also their coordination compounds have been recognized as potentially important in biological systems and as pharmaceutical drugs. Many of the 3d metal complexes revealed antitumor, antiviral, antimicrobial, antifungal, antidiabetic, antioxidants, antiproliferative and anti-inflammatory agents as well as anti-Alzheimer disease. In most cases, the complexes revealed superior activity than that exhibited by their parent free ligands.

This Special Issue is aimed to shed light on the recent developments of the rich 3d coordination complexes as potential biological active compounds emphasizing their roles as anticancer, antiviral, antimicrobial, antifungal and anti-inflammatory agents.

Prof. Dr. Salah Massoud
Prof. Dr. Febee Rophail Y. Louka
Dr. Francois Villinger
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • 3d metal complexes
  • anticancer
  • antiviral
  • antimicrobial
  • antifungal
  • anti-inflammatory agents

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Published Papers (1 paper)

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Research

14 pages, 2619 KiB  
Article
«Green-Ligand» in Metallodrugs Design—Cu(II) Complex with Phytic Acid: Synthetic Approach, EPR-Spectroscopy, and Antimycobacterial Activity
by Kseniya A. Koshenskova, Natalia V. Makarenko, Fedor M. Dolgushin, Dmitriy S. Yambulatov, Olga B. Bekker, Matvey V. Fedin, Sergei A. Dementev, Olesya A. Krumkacheva, Igor L. Eremenko and Irina A. Lutsenko
Molecules 2025, 30(2), 313; https://doi.org/10.3390/molecules30020313 - 15 Jan 2025
Viewed by 1006
Abstract
The interaction of sodium phytate hydrate C6H18O24P6·xNa·yH2O (phytNa) with Cu(OAc)2·H2O and 1,10-phenanthroline (phen) led to the anionic tetranuclear complex [Cu4(H2O)4(phen)4(phyt)]·2Na+ [...] Read more.
The interaction of sodium phytate hydrate C6H18O24P6·xNa·yH2O (phytNa) with Cu(OAc)2·H2O and 1,10-phenanthroline (phen) led to the anionic tetranuclear complex [Cu4(H2O)4(phen)4(phyt)]·2Na+·2NH4+·32H2O (1), the structure of the latter was determined by X-ray diffraction analysis. The phytate 1 is completely deprotonated; six phosphate− fragments (with atoms P1–P6) are characterized by different spatial arrangements relative to the cyclohexane ring (1a5e conformation), which determines two different types of coordination to the complexing agents—P1 and P3, P4, and P6 have monodentate, while P2 and P5 are bidentately bound to Cu2+ cations. The molecular structure of the anion complex is stabilized by a set of strong intramolecular hydrogen bonds involving coordinated water molecules. Aromatic systems of phen ligands chelating copper ions participate in strong intramolecular and intermolecular π-π interactions, further contributing to their association. At the supramolecular level, endless stacks are formed, in the voids of which sodium and ammonium cations and water molecules are present. The stability of 1 in the presence of human serum albumin (HSA) was investigated using Electron Paramagnetic Resonance (EPR) spectroscopy. Continuous wave (CW) EPR spectra in water/glycerol frozen solution clearly indicate a presence of an exchange-coupled Cu(II)-Cu(II) dimeric unit, as well as a Cu(II) monomer-like signal arising from spins sufficiently distant from each other, with comparable contributions of two types of signals. In the presence of albumin at a 1:1 ratio (1 to albumin), the EPR spectrum changes significantly, primarily due to the reduced contribution of the S = 1 fraction showing dipole–dipole splitting. The biological activity of 1 in vitro against the non-pathogenic (model for Mycobacterium tuberculosis) strain of Mycolicibacterium smegmatis is comparable to the first-line drug for tuberculosis treatment, rifampicin. Full article
(This article belongs to the Special Issue Coordination Complexes of 3d Metals as Anticancer, Antiviral, Antimicrobial, Antifungal and Anti-inflammatory Agents)
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