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Special Issue "Therapeutic Nucleic Acids: Past, Present, and Future"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Nanochemistry".

Deadline for manuscript submissions: 15 November 2018

Special Issue Editor

Guest Editor
Dr. Marina A. Dobrovolskaia

Nanotechnology Characterization Lab, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA
Website | E-Mail
Interests: immunology; toxicology; nanoparticles

Special Issue Information

Dear Colleagues,

The goal of this Special Issue is to review achievements and lessons learned from basic research and translational studies related to moving therapeutic nucleic acids from bench to bedside. The issue will include review and research articles, focusing on both traditional nucleic acids (e.g., antisense oligonucleotides, siRNA) and a new generation molecules (e.g., sgRNA, DNA origami, DNA/RNA nanoparticles). Challenges with the delivery of therapeutic nucleic acids and solutions for overcoming the challenges will be addressed by experts in the field. Nanotechnology-based delivery platforms, safety, efficacy, biomarkers,  and appropriate in vivo/in vitro models will be considered. We welcome you to share your research findings, literature reviews and technical recommendations in the subject area by submitting your work to this Special Issue.

Dr. Marina A. Dobrovolskaia
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Therapeutic oligonucleotides
  • Therapeutic RNA (RNAi, miRNA, mRNA)
  • DNA origami
  • RNA nanoparticles
  • DNA nanoparticles

Published Papers

This special issue is now open for submission.
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