Synthesis, Characterization and Biological Activity of Heterocyclic Compounds

Dear Colleagues,

Heterocycles are compounds with a ring-shaped structure containing one or more non-carbon atoms. Research into heterocyclic compounds dates back to the discovery of molecules such as alloxan and morphine. Research continued into the structural elucidation of nucleotides, vitamins, amino acids, and antibiotics. Today, heterocycles are the focus of research in various branches of chemistry.

In organic synthesis, heterocycles are not only target molecules; they also serve as reagents, protecting groups, solvents, and catalysts. Most biologically active compounds contain a heterocyclic motif. An analysis of FDA reports over the past 10 years reveals that 80% of approved small-molecule drugs contain an N-heterocycle core. Among these, five-membered, six-membered, and fused N-heterocycles are most prevalent, with the majority of these approved small molecules being cancer therapeutics.

The following Special Issue focuses on the preparation, identification, potential mechanism of action, biological activity, and structure–activity relationships of heterocyclic compounds. We hope to receive research articles, short communications, and reviews that explore current trends and possible future perspectives in this dynamic and extensive field of medicinal chemistry.

Dr. Luka Krstulović
Dr. Kristina Starčević
Guest Editors

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