Radiofluorination Chemistry: New Concepts and Techniques
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (31 December 2019) | Viewed by 293
Special Issue Editors
Interests: imaging biomarkers; radiopharmaceuticals
Interests: : radio-chemistries; radiolabeling of peptides; proteins and small molecular compounds for Positron Emission Tomography imaging; synthesis of radiolabeled nano-particles for cancer imaging; labeling of kinase substrates for imaging neurodegeneration
Special Issue Information
Dear Colleagues,
The PET image as a biomarker is created by radiotracers labeled with positron emitters with a clear preference and dominance for fluorine-18 (t1/2=109.8 min, 18F). The synthesis of 18F-labeled radiotracers requires innovative radiochemistry for the rapid and effective incorporation of 18F under conditions compatible with the structural and functional integrity of the target compounds. This Special Issue will discuss new radiochemistry concepts and techniques for the preparation of 18F-labeled compounds with a special emphasis on radiofluorine-acceptor chemistry, umpolung, late-stage radio-fluorinations, and transition-metal-mediated cross-coupling reactions.
Prof. Dr. Frank Wuest
Prof. Dr. Ralf Schirrmacher
Guest Editors
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Keywords
- Radiofluorine-acceptor chemistry
- Umpolung
- Late-stage radiofluorinations
- Transition-metal-mediated cross-couplings
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