Supercritical Fluid Extraction of Natural Bioactive Compounds
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".
Deadline for manuscript submissions: closed (30 April 2025) | Viewed by 1589
Special Issue Editors
Interests: eco-extraction; separative methods; mass spectrometry; metabolomics; natural compounds; active ingredients; cosmetics
Interests: supercritical fluids; interaction and solubility studies; stationary phases classifications; dynamic selective sequential green extraction; on line SFE-SFC
Special Issue Information
Dear Colleagues,
Today, there is a growing interest in sustainable approaches to the extraction and isolation of targeted compounds from various types of complex matrixes; this includes, for example, from plants.
Due to safety and the demand for sustainable development, numerous extraction methods have been developed in order to replace organic solvents. Pressurized fluids or dynamic extraction processes often favor the application of diffusion kinetics or/and exchange surfaces, and reduce the length of the extraction process.
Supercritical Fluid Extraction (SFE), which is based on the use of pure carbon dioxide or carbon dioxide-modified fluids, fulfills many of the requirements of green chemistry and the industrial economical model; this is especially due to the spontaneous obtention of a concentrated extract.
Many aspects regarding the use of SFE can be addressed, including the application of classical extraction methods such as the ratio fluid/matrix, the particle size, the sample moisture, the pressure and temperature, the nature of the modifier, and the use of a natural solvent for safety issues. Due to the significant number of experimental parameters, experimental designs are often built both to model the extraction kinetics and to provide more suitable conditions. Moreover, in the presence of varied compound families, selective conditions can be reached, enabling their sequential extraction from the same sample. In addition, significant work is required to achieve the correct molecular characterization of the obtained extract, and activity tests that indicate its suitable use in nutraceutical, pharmaceutic or cosmetic applications need to be performed. With this, the eventual upgrade from laboratory to industrial process will be achieved.
Therefore, this Special Issue of Molecules aims to provide an overview of recent advances in the processes used for the supercritical extraction of bioactive natural compounds, the pre-treatment of samples, and the attainment of experimental data and properties of extracts.
We warmly invite our colleagues to contribute to this Special Issue, which addresses the use of an unusual and versatile fluid.
Prof. Dr. Émilie Destandau
Prof. Dr. Eric Lesellier
Guest Editors
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Keywords
- supercritical fluid extraction
- natural bioactive compounds
- extraction efficiency
- sequential isolation
- bioactivity and chemical structure
- integrated processes
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