Nicotinic Receptors: Pharmacological Studies, Design and Synthesis of Pharmacologically Active Substances

Dear Colleagues,

Nicotinic ligands are involved in many different physiological and pathological processes, as well as an important drug target for several conditions, and they represent a topic of intense interest in medicinal chemistry. A better understanding of the receptor pharmacology provides a deeper insight into the mechanism of ligand binding, and ligand selectivity and the discovery of compounds able to modulate nicotinic acetylcholine receptors are important for achieving subtype selectivity, for obtaining pharmacological tools, and for studying nicotinic receptors. This Special Issue welcomes original articles, reviews, and short communications on all aspects of nicotinic receptors, including structural and computational studies, drug design and medicinal chemistry, biochemical and pharmacological studies, and structure–activity relationships on synthetic and natural ligands (also snake and snail venoms) with distinct properties (agonists, antagonists, partial agonists, silent agonists, allosteric modulators and ligands acting at multiple targets).

Dr. Dina Manetti
Guest Editor

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