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Natural Pharmacons: Biologically Active Plant-Derived Pharmaceuticals

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 1939

Special Issue Editor


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Guest Editor
Institute for Research in Molecular Medicine, Universiti Sains Malaysia, 11800 USM, Pe-nang, Malaysia
Interests: anticancer; antiaging; polyphenol; medicinal plants; apoptosis; microRNA

Special Issue Information

Dear Colleagues,

Cancer and aging is a serious problem worldwide and leads to a significant threat to human health. Cancer incidence also has a substantial impact on fast aging. There has been continued progress in anticancer and antiaging agent development during the last few years.

Biologically active plant-derived pharmaceuticals were a novel target for such new agent development. Plant-derived pharmaceutical activates oxidative stress, apoptosis and endoplasmic reticulum stress to inhibit cell proliferation, migration and invasion in cancer and, at the same time, delay the aging process by inhibiting such activation in normal cells. Interestingly, the plant-derived pharmaceutical can work well in cancer and normal cells to induce anticancer and antiaging activity by switching their role in particular cells with different events. 

This Special Issue on “Natural Pharmacons: Biologically Active Plant-Derived Pharmaceuticals” aims to be an open forum where researchers may share their experiences and findings in this promising field. It is focused on the comprehensive and critical examination of current and emerging research on the design and development of advanced anticancer or antiaging agents from plant-derived pharmaceuticals and their application to experimental and clinical therapeutics. Contributions to this issue, in the form of both original research and review articles, may cover all aspects of the discovery and development of new therapeutic agents for cancer with antiaging properties for prolonging the overall survival of cancer patients using the latest biotechnology, pharmacology, and genetic engineering techniques in cellular and animal model.

Dr. Sreenivasan Sasidharan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • anticancer
  • antiaging
  • apoptosis
  • oxidative stress
  • endoplasmic reticulum stress
  • antioxidant
  • medicinal plants
  • polyphenol

Published Papers (1 paper)

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Research

13 pages, 2637 KiB  
Article
Study on Synergistic Anti-Inflammatory Effect of Typical Functional Components of Extracts of Ginkgo Biloba Leaves
by Lihu Zhang, Xianying Fang, Jihu Sun, Erzheng Su, Fuliang Cao and Linguo Zhao
Molecules 2023, 28(3), 1377; https://doi.org/10.3390/molecules28031377 - 01 Feb 2023
Cited by 1 | Viewed by 1694
Abstract
There are some differences in the anti-inflammatory activities of four typical components in EGB (extracts of ginkgo biloba leaves), and there is also a synergistic relationship. The order of inhibiting the NO-release ability of single functional components is OA > GF > OPC [...] Read more.
There are some differences in the anti-inflammatory activities of four typical components in EGB (extracts of ginkgo biloba leaves), and there is also a synergistic relationship. The order of inhibiting the NO-release ability of single functional components is OA > GF > OPC > G. Ginkgolide (G), proanthocyanidins (OPC), and organic acids (OA) all have synergistic effects on ginkgo flavonoids (GF). GF:OA (1:9) is the lowest interaction index among all complexes, showing the strongest synergy. The anti-inflammatory mechanism of the compound affects the expression of p-JNK, p-P38, and p-ERK1/2 proteins by inhibiting the expression of iNOS and COX2 genes on NFKB and MAPK pathways. This also provides a research basis for the development of anti-inflammatory deep-processing products of EGB. Full article
(This article belongs to the Special Issue Natural Pharmacons: Biologically Active Plant-Derived Pharmaceuticals)
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