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Biotransformation of Medicinal Nanostructures: Pharmacokinetics and Pharmacodynamics

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Molecular Structure".

Deadline for manuscript submissions: closed (31 October 2022) | Viewed by 5087

Special Issue Editor


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Guest Editor
Department of Medical Nanobiotechnologies, Russian National Research Medical University, 117997 Moscow, Russia
Interests: paramagnetic metal isotopes and nanocationites in cancer research

Special Issue Information

Dear Colleagues,

Molecules is now announcing a call for submissions to the Special Issue entitled “Biotransformation of Medicinal Nanostructures: Pharmacokinetics and Pharmacodynamics”. This issue will deal with the most recent achievements in basic research on molecular and cellular nanopharmacology and related subjects such as xenobiochemistry, drug metabolism, efficiency, and bioavailability of biologically active nanocompounds, drug–target interactions, ligand–receptor coupling, advanced methods in analytical biochemistry, and detection–quantification of nanopharmacophores. In silico simulation models would also be welcomed.

Some specific aspects of preclinical nanomedicine studies including in-cell internalization of pharmacophores, visualization of tumor, and nanocontainers in drug targeted delivery cases taken in a broad variety of pathologies (cancers, infectious diseases, autoimmune disorders, etc.) are also expected to be focused on—as long as these studies relate to nanodrug metabolism and its pharmacological potential.

Manuscript formats adopted by Molecules may additionally include the following types of papers: articles, reviews, communications, brief reports, etc.

Prof. Dr. Dmitry A. Kuznetsov
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Medicinal nanoparticles
  • Drug targeting
  • Pharmacokinetics
  • Nanoparticle biotransformation
  • Nanodrug–target coupling
  • In silico nanopharmacodynamics models
  • Advanced techniques in detection of nanodrugs in vivo

Published Papers (2 papers)

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Research

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9 pages, 1211 KiB  
Communication
New Cysteine-Containing PEG-Glycerolipid Increases the Bloodstream Circulation Time of Upconverting Nanoparticles
by Maria E. Nikolaeva, Andrey V. Nechaev, Elena V. Shmendel, Roman A. Akasov, Mikhail A. Maslov and Andrey F. Mironov
Molecules 2022, 27(9), 2763; https://doi.org/10.3390/molecules27092763 - 26 Apr 2022
Cited by 1 | Viewed by 1486
Abstract
Upconverting nanoparticles have unique spectral and photophysical properties that make them suitable for development of theranostics for imaging and treating large and deep-seated tumors. Nanoparticles based on NaYF4 crystals doped with lanthanides Yb3+ and Er3+ were obtained by the high-temperature [...] Read more.
Upconverting nanoparticles have unique spectral and photophysical properties that make them suitable for development of theranostics for imaging and treating large and deep-seated tumors. Nanoparticles based on NaYF4 crystals doped with lanthanides Yb3+ and Er3+ were obtained by the high-temperature decomposition of trifluoroacetates in oleic acid and 1-octadecene. Such particles have pronounced hydrophobic properties. Therefore, to obtain stable dispersions in aqueous media for the study of their properties in vivo and in vitro, the polyethylene glycol (PEG)-glycerolipids of various structures were obtained. To increase the circulation time of PEG-lipid coated nanoparticles in the bloodstream, long-chain substituents are needed to be attached to the glycerol backbone using ether bonds. To prevent nanoparticle aggregation, an L-cysteine-derived negatively charged carboxy group should be included in the lipid molecule. Full article
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16 pages, 1563 KiB  
Perspective
Temozolomide Efficacy and Metabolism: The Implicit Relevance of Nanoscale Delivery Systems
by Daria Petrenko, Vladimir Chubarev, Nikita Syzrantsev, Nafeeza Ismail, Vadim Merkulov, Susanna Sologova, Ekaterina Grigorevskikh, Elena Smolyarchuk and Renad Alyautdin
Molecules 2022, 27(11), 3507; https://doi.org/10.3390/molecules27113507 - 30 May 2022
Cited by 5 | Viewed by 3170
Abstract
The most common primary malignant brain tumors in adults are gliomas. Glioblastoma is the most prevalent and aggressive tumor subtype of glioma. Current standards for the treatment of glioblastoma include a combination of surgical, radiation, and drug therapy methods. The drug therapy currently [...] Read more.
The most common primary malignant brain tumors in adults are gliomas. Glioblastoma is the most prevalent and aggressive tumor subtype of glioma. Current standards for the treatment of glioblastoma include a combination of surgical, radiation, and drug therapy methods. The drug therapy currently includes temozolomide (TMZ), an alkylating agent, and bevacizumab, a recombinant monoclonal IgG1 antibody that selectively binds to and inhibits the biological activity of vascular endothelial growth factor. Supplementation of glioblastoma radiation therapy with TMZ increased patient survival from 12.1 to 14.6 months. The specificity of TMZ effect on brain tumors is largely determined by special aspects of its pharmacokinetics. TMZ is an orally bioavailable prodrug, which is well absorbed from the gastrointestinal tract and is converted to its active alkylating metabolite 5-(3-methyl triazen-1-yl)imidazole-4-carbozamide (MTIC) spontaneously in physiological condition that does not require hepatic involvement. MTIC produced in the plasma is not able to cross the BBB and is formed locally in the brain. A promising way to increase the effectiveness of TMZ chemotherapy for glioblastoma is to prevent its hydrolysis in peripheral tissues and thereby increase the drug concentration in the brain that nanoscale delivery systems can provide. The review discusses possible ways to increase the efficacy of TMZ using nanocarriers. Full article
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