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Research on Plant-Based Polyphenols: Extraction, Purification and Application

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 31 May 2026 | Viewed by 1162

Special Issue Editors


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Guest Editor
Department Design and Green Engineering, Salzburg University of Applied Sciences, Kuchl, Austria
Interests: wood sciences and technology; green extraction methods; material valorization
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department Design and Green Engineering, Salzburg University of Applied Sciences, Kuchl, Austria
Interests: biopolymers; tannins; organic-inorganic hybrids; porous materials; green chemistry; sustainable resin systems

Special Issue Information

Dear Colleagues,

We are pleased to invite you to share your research regarding the extraction and application of plant-based polyphenols. Tree extracts possess a range of properties and have been associated with excellent results in various applications and fields. Polyphenols are valuable resources, with tannins representing a particularly versatile family of plant-derived polyphenolic molecules and protecting trees against fungi, herbivores and insects. Depending on the source, this wide group of oligomeric compounds can be separated into four main groups: (i) hydrolysable tannins, which are carbohydrate esters of gallic and ellagic acid; (ii) condensed tannins, which are oligomeric flavan-3-ols or proanthocyanidins; (iii) phlorotannins, which are mostly found in algae; and (iv) complex tannins. Tannins contain aromatic rings and hydroxy groups that render them reactive in various ways.

Due to the high availability of raw materials (bark, leaves, fruits, algae, etc.) and their ease of extraction, plant-based polyphenols are attracting enhanced interest from the scientific and industrial community. Current applications of polyphenols include leather tannery, the synthesis of various types of resins with different crosslinkers, and the production of porous polymers such as foams and aerogels. These materials are mainly used in, but not limited to, insulation, the production of engineered wood products, soil amendment, effluent and wastewater treatment and water storage.

This Special Issue aims to provide an overview of recent innovations in extraction techniques, purification, separation, fermentation procedures and the advanced characterization of plant-based polyphenols and their innovative applications. Therefore, the articles submitted to this Special Issue should highlight novel extraction techniques, propose the valorization of untapped resources, and provide new perspectives on the application and synthesis of tannin and polyphenol-based materials, as well as tannins themselves.  

In this Special Issue, original research articles and reviews are welcome. The scope of this Special Issue includes, but is not limited to, the following topics:

  • Novel extraction techniques;
  • Valorization of untapped tannin sources;
  • Separation, purification and advanced characterization;
  • The application of tannins in material synthesis;
  • Use of plant-based polyphenols in health and nutrition;
  • Resin and polymer application.

We look forward to receiving your contributions.

Prof. Dr. Thomas Schnabel
Dr. Thomas Sepperer
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • condensed tannin
  • biopolymers
  • extraction
  • circular economy
  • deep eutectic solvent
  • hydrolysable tannin
  • residue valorization

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Published Papers (1 paper)

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Research

21 pages, 2831 KB  
Article
Chemical Characterization and Protective Effects of a Subcritical Water Extract from Olive Pomace Against Dyslipidemia and Hepatic Steatosis in High-Fat/High-Sugar Diet–Fed Mice
by Alicia Ochoa-Acosta, Analy Aispuro-Pérez, Feliznando Cárdenas-Torres, Mayra Arias-Gastelum, Marco Antonio Valdez-Flores, María de la Paz Espinoza, Julio Montes-Avila, Bianca Amezquita-López, Roberto Avena-Bustillos, Selina C. Wang, Eli Terán-Cabanillas and Ulises Osuna-Martínez
Molecules 2026, 31(6), 995; https://doi.org/10.3390/molecules31060995 - 16 Mar 2026
Viewed by 540
Abstract
Olive pomace, a byproduct of olive oil production, is a rich source of bioactive phenolic compounds with potential health benefits. This study aimed to characterize the chemical composition and evaluate the metabolic effects of a subcritical water extract from California olive pomace (SWE [...] Read more.
Olive pomace, a byproduct of olive oil production, is a rich source of bioactive phenolic compounds with potential health benefits. This study aimed to characterize the chemical composition and evaluate the metabolic effects of a subcritical water extract from California olive pomace (SWE COP) obtained from Arbequina olives. The extract was mainly composed of carbohydrates (72.81%) and contained 66.62 ± 1.22 mg gallic acid equivalents/g of phenolics, with 3,4-DHPEA-EDA, hydroxytyrosol, and verbascoside identified as the predominant compounds. Male C57BL/6N mice were fed a standard diet (SD; n = 7), a high-fat and high-sugar diet (HFSD; n = 7), which was used to induce features of diet-associated metabolic syndrome, or an HFSD supplemented with 3% (w/w) SWE COP (n = 7) for 16 weeks. Supplementation with SWE COP significantly reduced plasma triglycerides and increased HDL cholesterol levels compared with the HFSD group. Moreover, SWE COP improved glucose tolerance, enhanced insulin sensitivity, and reduced mesenteric and epididymal adiposity. Histological analysis showed that SWE COP alleviated hepatic steatosis and lowered the NAFLD activity score. These findings demonstrate that phenolic-rich SWE COP exerts beneficial effects on glucose and lipid metabolism and reduces liver fat accumulation in diet-induced obese mice. Overall, SWE COP represents a promising functional ingredient derived from olive industry byproducts for mitigating metabolic dysfunctions associated with obesity. Full article
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