Endocannabinoid System Modulators in a Medicinal Chemistry Perspective II
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 164
Special Issue Editors
Interests: flavonoids; drug design; hybrid molecules; MDR reversal; neurodegeneration
Special Issues, Collections and Topics in MDPI journals
Interests: drug design; flavonoids; hybrid molecules; cytochromes P-450 inhibitors; privileged structures; breast cancer; Alzheimer’s disease; CB receptor ligands
Special Issue Information
Dear Colleagues,
Currently, the term “endocannabinoid system” (ECS) includes endogenous cannabinoids (endocannabinoids, mainly anandamide and 2-arachidonoylglycerol), the enzymes involved in their biosynthesis, transport and degradation and the G protein-coupled receptors (cannabinoid receptors, CBRs) with which they interact. In recent years, it has become clear that the ECS is up-regulated in numerous pathophysiological states such as inflammatory, neurodegenerative, gastrointestinal, metabolic and cardiovascular diseases, pain and cancer, and that its modulation offers significant potential for intervention in different areas of human health. This Special Issue aims to provide an overview of the latest studies on potential drugs acting on this challenging system, both involving the cannabinoid receptors and/or the enzymes responsible for endocannabinoids transport and hydrolysis, recognized as validated targets in medicinal chemistry.
Dr. Alessandra Bisi
Dr. Silvia Gobbi
Guest Editors
Manuscript Submission Information
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Keywords
- CB ligands
- FAAH inhibitors
- MAGL inhibitors
- reuptake inhibitors
- neurodegeneration
- pain
- cancer
