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Polymeric Nano-Based Drug Delivery Systems

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Macromolecular Chemistry".

Deadline for manuscript submissions: 30 September 2026 | Viewed by 679

Special Issue Editor


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Guest Editor
Centro de Investigacion en Quimica Aplicada, Saltillo 25294, Mexico
Interests: heterophase polymerization; microemulsions; nanodevices; polymeric drug carriers; inorganic heterostructures; cancer treatment
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Special Issue Information

Dear Colleagues,

The advent of nanotechnology has opened the door to numerous applications, from electronics to novel materials and pharmaceuticals at the nanoscale level (<100 nm). Drug delivery systems (DDSs) based on polymers have become a research area of increasing interest in recent years. Conventional treatment of diseases is limited by factors that operate against an efficient uptake of the drugs e.g., poor solubility, low bioavailability, degradation, residence time in the organism, secondary effects, and dynamic barriers. Polymeric nano-based drug carriers improve the efficacy of drug delivery and, at the same time, protect the drug from severe environments (e.g., gastrointestinal) and reactions of the organism such as phagocytosis in parenteral administration. The encapsulation of drugs in polymeric nano-carriers provides an efficient route to incorporate hydrophobic drugs, including essential oils (EOs) from plant materials. An EO could be used as a vehicle to dissolve the active ingredient, and polymers could be used to nano-encapsulate the solution, providing a drug protection system with a potential synergistic effect. Potentially, polymeric nano-based DDSs could efficiently overcome dynamic barriers such as the blood-brain barrier, a drawback in treating brain diseases, such as Alzheimer's, Parkinson's, and brain tumors.

Researchers from diverse backgrounds who are interested in applying polymers to design drug nano-carriers are invited to contribute to the “Polymeric Nano-Based Drug Delivery Systems” Special Issue with original research articles, review papers, and short communications to report the most recent advances in this area.

Dr. René Darío Peralta-Rodríguez
Guest Editor

Manuscript Submission Information

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Keywords

  • nanotechnology
  • polymers
  • biopolymers
  • drug delivery
  • encapsulation
  • essential oils
  • blood-brain barrier

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Published Papers (1 paper)

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Research

20 pages, 1491 KB  
Article
Development of PDMS Films Containing Thiamine Bromide and Sodium Iodide: Part 1—Matrix Characterisation and In Vitro Release
by Zoya Farmazyan, Nelli Avagyan, Vigen Topuzyan, Emma Arakelova, Stepan Grigoryan, Mari Atabekyan, Susanna Grigoryan, Karen Khachatryan and Gohar Khachatryan
Molecules 2026, 31(10), 1588; https://doi.org/10.3390/molecules31101588 - 9 May 2026
Viewed by 150
Abstract
This article represents the initial preformulation stage of a broader project aimed at evaluating polysiloxane films as carrier matrices for the TIODIN components thiamine bromide (ThBr) and sodium iodide (NaI). The specific gap addressed in this first part is the lack of information [...] Read more.
This article represents the initial preformulation stage of a broader project aimed at evaluating polysiloxane films as carrier matrices for the TIODIN components thiamine bromide (ThBr) and sodium iodide (NaI). The specific gap addressed in this first part is the lack of information on how these two highly water-soluble crystalline salts are incorporated into hydrophobic crosslinked PDMS-based matrices, how they are distributed within such films, what solid-state forms and interactions may arise, and how these features relate to their release behaviour. Crosslinked films were prepared from α,ω-dihydroxypolydimethylsiloxane (PDMS–OH) of different viscosities, tetraethoxysilane (TEOS), and Sn(Oct)2 as a catalyst. Raman spectroscopy, confocal Raman depth profiling, and X-ray diffraction showed that the films contain both individual ThBr and NaI crystallites and mixed crystalline domains consistent with partial ThBr/NaI association and/or iodide-exchanged phases. The fraction of such mixed domains was higher in films prepared from lower-viscosity PDMS–OH than in films based on higher-viscosity PDMS–OH, and depth profiling extended this trend into the accessible near-surface layers from both film sides. Release into physiological saline, used here as a simple comparative aqueous release medium, remained low, reaching approximately 9% for ThBr and 20% for NaI after 72 h, while film swelling was minimal, approximately 1–1.5%. These findings are consistent with restricted water penetration and diffusion-limited release from hydrophobic, weakly swelling matrices. Because this first part of the study is restricted to matrix characterisation, depth profiling, and release into saline, the present results should be regarded as preformulation data. They do not demonstrate skin permeation, therapeutic transdermal performance, or suitability as a complete patch dosage form but establish baseline structural and release characteristics for a planned Part 2 focused on more application-oriented film optimisation, including properties required for future transdermal patch development. Full article
(This article belongs to the Special Issue Polymeric Nano-Based Drug Delivery Systems)
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