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Natural Bioactives and Functional Ingredients in Foods

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Food Chemistry".

Deadline for manuscript submissions: 16 May 2026 | Viewed by 660

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Guest Editor
Centro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, Bragança, Portugal
Interests: food technologies; bioactive compounds; bio-waste recovery; food innovation; sustainable research
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The growing interest in foods with functional properties has driven research focused on the identification, characterization, and application of natural bioactive compounds in food matrices. These ingredients, derived from plants, algae, microorganisms, and agro-industrial by-products, play a key role in promoting health and preventing non-communicable chronic diseases. This Special Issue gathers innovative studies on the extraction, stability, bioavailability, mechanisms of action, and physiological effects of natural bioactives such as polyphenols, carotenoids, bioactive peptides, prebiotics, and other functional ingredients. It also addresses technological strategies for incorporating these compounds into foods and beverages, as well as the regulatory and sensory challenges related to their use. This Issue aims to foster scientific exchange among researchers, industry professionals, and policymakers, promoting the advancement of knowledge and the development of healthier and more sustainable foods.

Dr. Cristina Caleja
Guest Editor

Manuscript Submission Information

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Keywords

  • natural bioactive compounds
  • functional food ingredients
  • health-promoting foods
  • nutraceuticals
  • food innovation

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Published Papers (1 paper)

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Research

19 pages, 3628 KB  
Article
Structural Characterization and Protective Effects of CPAP-1, an Arabinogalactan from Curcuma phaeocaulis Val., Against H2O2-Induced Oxidative Damage in HUVECs
by Yuhao Long, Sirui Yi, Huizhi Zhou, Fangrou Chen, Yiping Guo and Li Guo
Molecules 2025, 30(22), 4340; https://doi.org/10.3390/molecules30224340 - 9 Nov 2025
Viewed by 455
Abstract
Curcuma phaeocaulis, a perennial herb of the ginger family, has been used to treat many diseases in traditional medicine systems. This study aimed to extract, isolate, and purify a homogeneous polysaccharide from C. phaeocaulis, conduct preliminary structural characterization, and evaluate its [...] Read more.
Curcuma phaeocaulis, a perennial herb of the ginger family, has been used to treat many diseases in traditional medicine systems. This study aimed to extract, isolate, and purify a homogeneous polysaccharide from C. phaeocaulis, conduct preliminary structural characterization, and evaluate its antioxidant activity at the cellular level. The structure of the purified polysaccharide (CPAP-1) was characterized using size exclusion chromatography (SEC), chemical derivatization analysis (CDA), GC-MS, FT-IR, and NMR. The results showed that CPAP-1 has an apparent molecular weight of 118.122 kDa and is hypothesized to be an arabinogalactan with a backbone composed of →3,6)-β-d-Galp-(1→ and →3)-β-d-Galp-(1→ residues, a structure that is relatively novel in Curcuma longa. In vitro antioxidant assays demonstrated that CPAP-1 possesses potent antioxidative stress activity, effectively scavenging both DPPH and hydroxyl radicals. Furthermore, cellular experiments revealed that at concentrations of 500 and 750 mg/L, CPAP-1 significantly protected human umbilical vein endothelial cells (HUVECs) against H2O2-induced oxidative damage. In conclusion, these findings suggest that CPAP-1 could be developed as a natural antioxidant, functional food, or therapeutic agent for preventing and mitigating oxidative stress-related vascular injury, providing a theoretical basis for further development and application. Full article
(This article belongs to the Special Issue Natural Bioactives and Functional Ingredients in Foods)
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