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Molecules
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Green Biosensors for Clinical Diagnostics, Food, and Environmental Monitoring
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Green Biosensors for Clinical Diagnostics, Food, and Environmental Monitoring

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Chemical Biology".

Deadline for manuscript submissions: closed (15 June 2023) | Viewed by 3430

Special Issue Editors

Dr. Rossella Svigelj

E-Mail Website
Guest Editor
Department of Agrifood, Environmental and Animal Science, University of Udine, Via Cotonificio 108, 33100 Udine, Italy
Interests: aptasensors; biosensors; deep eutectic solvents; electrochemistry; food analysis; allergens
Dr. Rebeca Miranda-Castro

E-Mail Website
Guest Editor
Department of Physical and Analytical Chemistry, University of Oviedo, Julián Clavería 8, 33006 Oviedo, Spain
Interests: aptamers; electrochemistry; nucleic acid-based biosensors; DNA isothermal amplification; clinical diagnosis; food safety control
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

There is a growing demand today for low-cost, fast, and green sensors for monitoring chemical species, and xenobiotics in clinical chemistry, environmental sciences, and food-related processes. Effective methods for the detection of food contaminants, pathogens, or biomarkers are becoming crucial to improve public health. Biosensors offer many advantages since they can be easily used in both laboratory and field applications and are easy to use without the need for a skilled operator, as well as automatic, cheap, and with no need for maintenance and sample pre-treatments. 

In this Special Issue, we seek manuscripts which cover the development of biosensors for analytes involved in public health, with attention to the use of green and sustainable materials. Indeed, the use of materials such as paper or deep eutectic solvents (DESs) can contribute to the development of point-of-care sensors (POCs) to ensure public health using sustainable materials. Potential topics include but are not limited to aspects regarding the development of biosensors for allergens, pesticides, and cancer biomarkers, exploiting the use of green materials such as paper, DES, or biochar.

Dr. Rossella Svigelj
Dr. Rebeca Miranda-Castro
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • aptasensors
  • biosensors
  • green analytical chemistry
  • deep eutectic solvents
  • paper-based sensors
  • food analysis
  • emerging contaminants
  • biomarkers

Published Papers (2 papers)

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Research

10 pages, 22438 KiB  
Article
CSDR Coupling with Exo III for Ultrasensitive Electrochemistry Determination of miR-145
by Moli Zhang, Yang Yang, Lingyi Xin, Hua Zhang, Lun Wu, Jun Zhu, Jing Zhu, Shiyun Liu, Zhaohui Wang, Qinhua Chen and Guangyi Yang
Molecules 2023, 28(5), 2208; https://doi.org/10.3390/molecules28052208 - 27 Feb 2023
Viewed by 1288
Abstract
Recently, miRNAs have become a promising biomarker for disease diagnostics. miRNA-145 is closely related to strokes. The accuracy determination of miRNA-145 (miR-145) in stroke patients still remains challenging due to its heterogeneity and low abundance, as well as the complexity of the blood [...] Read more.
Recently, miRNAs have become a promising biomarker for disease diagnostics. miRNA-145 is closely related to strokes. The accuracy determination of miRNA-145 (miR-145) in stroke patients still remains challenging due to its heterogeneity and low abundance, as well as the complexity of the blood matrix. In this work, we developed a novel electrochemical miRNA-145 biosensor via subtly coupling the cascade strand displacement reaction (CSDR), exonuclease III (Exo III), and magnetic nanoparticles (MNPs). The developed electrochemical biosensor can quantitatively detect miRNA-145 ranging from 1 × 102 to 1 × 106 aM with a detection limit as low down as 100 aM. This biosensor also exhibits excellent specificity to distinguish similar miRNA sequences even with single-base differences. It has been successfully applied to distinguish healthy people from stroke patients. The results of this biosensor are consistent with the results of the reverse transcription quantitative polymerase chain reaction (RT-qPCR). The proposed electrochemical biosensor has great potential applications for biomedical research on and clinical diagnosis of strokes. Full article
(This article belongs to the Special Issue Green Biosensors for Clinical Diagnostics, Food, and Environmental Monitoring)
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12 pages, 2992 KiB  
Article
Development of a Lateral Flow Strip with a Positive Readout for the On-Site Detection of Aflatoxin B1
by Kemin Shen, Xiaoqin Hu, Linlin Sun, Chun Han and Jianzhou Yang
Molecules 2022, 27(15), 4949; https://doi.org/10.3390/molecules27154949 - 03 Aug 2022
Cited by 5 | Viewed by 1672
Abstract
Aflatoxin B1 is one of the contamination indicators for food safety monitoring. The rapid and effective assessment and determination of AFB1 in food is of great importance to dietary safety. The lateral flow assay shows advantages in its simplicity, and rapidity, [...] Read more.
Aflatoxin B1 is one of the contamination indicators for food safety monitoring. The rapid and effective assessment and determination of AFB1 in food is of great importance to dietary safety. The lateral flow assay shows advantages in its simplicity, and rapidity, and provides a visual readout, while the available lateral flow assay for AFB1 requires a competitive format that produces readings inversely proportional to the AFB1 concentration, which is counterintuitive and may lead to a potential misinterpretation of the results. Herein, we developed a positive readout aptamer-based lateral flow strip (Apt-strip) for the detection of AFB1. This Apt-strip relies on the competition between AFB1 and fluorescein-labeled complementary DNA strands (FAM-cDNA) for affinity binding to limited aptamers against AFB1 (AFB1-Apt). In the absence of AFB1, AFB1-Apt hybridizes with FAM-cDNA. No signal at the T-line of the Apt-strip was observed. In contrast, AFB1-Apt binds to AFB1 in the sample, and then a part of the FAM-cDNA is hybridized with the free AFB1-Apt, at which time the other unreacted FAM-cDNA is captured by A35-Apt on the T-line. The signal was observed. This method achieved fast detection of AFB1 with a detection limit (DL) of 0.1 ng/mL, positive readout, and increased sensitivity. Full article
(This article belongs to the Special Issue Green Biosensors for Clinical Diagnostics, Food, and Environmental Monitoring)
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