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Exploring the Antioxidant Properties of Natural Products

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 26 July 2026 | Viewed by 606

Special Issue Editors


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Guest Editor
Division of Vegetal-Based Food Technology, SECIHTI-Food and Development Research Centre, Hermosillo 83304, Mexico
Interests: revalorization of traditional foods from ancestral diets; use of tropical fruits byproducts and waste; developing and evaluating food products derived from non-conventional bioresources and by-products
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Biotechnology and Bioengineering Laboratory, Research Center in Food Development, Delicias 33089, Mexico
Interests: biochemical engineering; lipid biotechnology; biofuels; food science; nutrition; by-product valorization
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Bioactive compounds from plant sources, including flavonoids, phenolic acids, carotenoids, peptides, essential oils, carbohydrates, and essential micronutrients, are recognized as potent antioxidants that can scavenge and neutralize radical species, peroxides, and other molecules that promote oxidative stress. These compounds protect cellular macromolecules, maintaining cellular homeostasis and modulating oxidative pathways to prevent cellular damage, avoiding processes such as apoptosis. Moreover, their capacity to modulate signaling pathways can enhance the body's defense mechanisms against various disorders, including cancer and cardiovascular diseases. Therefore, it is essential to investigate the antioxidant properties of various natural resources and the mechanisms underlying their antioxidant actions, both in vivo and in vitro. Research on the mechanisms of action, bioavailability, and potential applications in nutrition and medicine is encouraged.

We invite original research and review articles on topics including, but not limited to, the following:

  • The function of antioxidants in preventing chronic diseases.
  • Antioxidant activity and its potential applications.
  • Beneficial potential of antioxidant-rich natural products.
  • Evaluation of antioxidant properties in agricultural byproducts.
  • Bioavailability and bioaccessibility of bioactive compounds.

Dr. Leticia Xochitl Lopez-Martinez
Prof. Dr. Ramiro Baeza-Jiménez
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • carotenoids
  • phenolic compounds
  • oxidative stress
  • health benefits
  • bioactive and nutritional molecules
  • essential oils
  • agricultural byproducts

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Published Papers (1 paper)

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Research

12 pages, 511 KB  
Article
Guava Byproducts (Psidium guajava L.) as a Source of Phenolic Compounds with In Vitro Antihyperlipidemic Potential
by Ramiro Baeza-Jiménez, Juan Antonio Noriega-Rodríguez, Mónica A. Villegas-Ochoa, Gustavo A. Gonzalez-Aguilar and Leticia X. López-Martínez
Molecules 2026, 31(10), 1647; https://doi.org/10.3390/molecules31101647 - 13 May 2026
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Abstract
Guava (Psidium guajava L.) processing produces peels, seeds, and residual pulp. Previous studies have shown that this fraction contains a significant amount of bioactive molecules (more than in the pulp), such as phenolic compounds, which have demonstrated health-beneficial bioactivities, including antioxidant, anti-obesogenic, [...] Read more.
Guava (Psidium guajava L.) processing produces peels, seeds, and residual pulp. Previous studies have shown that this fraction contains a significant amount of bioactive molecules (more than in the pulp), such as phenolic compounds, which have demonstrated health-beneficial bioactivities, including antioxidant, anti-obesogenic, and antihyperlipidemic activities, among others. In this study, we aimed to characterize total phenolic compounds, total flavonoids, the phenolic profile, and the in vitro antioxidant and antihyperlipidemic properties of guava byproduct extracts, which were evaluated for their potential use as functional ingredients. Phenolic analysis indicated the total phenolic content (46.45 mg GAE/g), the total flavonoid content (3.86 mg CE/g), and contents of individual phenolic compounds, namely ellagic, syringic, rutin, luteolin, and kaempferol. The extracts showed good antioxidant activity (236.22, 344.89, and 387.1 µmol TE/100 g for TEAC, DPPH, and FRAP, respectively). Moreover, the extracts could bind bile acids (18.50–40.34%) and reduce cholesterol solubility in artificial micelles (53.0–67.6%). Modest pancreatic lipase inhibition (33.33%), stronger cholesterol esterase inhibitory activities (60.22%), and mild HMG-CoA inhibitory potential (16.90%) were recorded. Guava processing byproducts demonstrate the potential to be considered as value-added ingredients in functional foods. Full article
(This article belongs to the Special Issue Exploring the Antioxidant Properties of Natural Products)
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