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Antitumor and Antiviral Potentials of Natural Products and Their Synthetic...
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Antitumor and Antiviral Potentials of Natural Products and Their Synthetic Analogs

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (31 July 2021) | Viewed by 5496

Special Issue Editor

Prof. Dr. Kyoko Nakagawa-Goto

E-Mail Website
Guest Editor
1. Associate Professor, School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences , Kakuma-machi, Kanazawa 920-1192, Japan
2. Adjunct Associate Professor, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hil, NC, USA
Interests: medicinal chemistry; drug discovery; natural products; antitumor; anti-virus; synthesis of bioactive compounds; chemical biology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cancer is the second leading cause of death worldwide, and almost 9.6 million people died from cancer in 2018. On the other hand, infectious diseases caused by viruses, fungi, bacteria, or protozoa, are the top cause of death in developing countries. In recent years, new viruses and pathogenic microorganisms have emerged causing cases of serious illness, called emerging infectious disease (EID). Among EIDs caused by viruses, AIDS has been known as a major global public health issue, and 38 million people in the world were living with HIV in 2019. Most recently, the pandemic of COVID-19 by SARS-CoV-2 has been another severe global issue. Besides, some viruses, such as hepatitis and human papillomavirus (HPV), are also known to be responsible for cancer cases. Therefore, drug discovery and development to overcome cancer and viruses is an urgent task for scientists in related fields.

Natural products have contributed significantly to drug discovery. Especially in the area of cancer, many of the mainstream of anticancer drugs came from natural products and their derivatives. One-third of antiviral drugs have also been discovered based on natural products.

This Special Issue will collect original research and review articles focusing on notable and recent contributions in the discovery and development of novel anticancer/antiviral drug candidates from the natural source. Their updated knowledge from the various research fields is welcome. This could be of great interest for multiple categories of scientists managing in the different research area, such as natural product chemistry including isolation and structural elucidation, phytochemistry, synthetic, and medicinal chemistry, including modified natural compounds with improved biological activity, pharmacology, chemical biology, molecular biology, and mechanisms of action study using natural products or their related compounds, and so on. The biological study of natural extracts without an appropriate chemical characterization will not be considered.


Prof. Dr. Kyoko Nakagawa-Goto
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products
  • natural product derivatives
  • synthetic derivatives inspired by natural scaffolds
  • total synthesis
  • phytochemistry
  • isolation and structural elucidation
  • drug discovery and development
  • antitumor/antiproliferative activity
  • chemosensitizer
  • cancer prevention
  • structure–activity relationship
  • mechanisms of action study
  • Chemical biology

Published Papers (2 papers)

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Research

13 pages, 2043 KiB  
Article
α-Trifluoromethyl Chalcones as Potent Anticancer Agents for Androgen Receptor-Independent Prostate Cancer
by Yohei Saito, Atsushi Mizokami, Kouji Izumi, Renato Naito, Masuo Goto and Kyoko Nakagawa-Goto
Molecules 2021, 26(9), 2812; https://doi.org/10.3390/molecules26092812 - 10 May 2021
Cited by 7 | Viewed by 2184
Abstract
α-Trifluoromethyl chalcones were prepared and evaluated for their antiproliferative activities against androgen-independent prostate cancer cell lines as well as five additional types of human tumor cell lines. The most potent chalcone 5 showed superior antitumor activity in vivo with both oral and intraperitoneal [...] Read more.
α-Trifluoromethyl chalcones were prepared and evaluated for their antiproliferative activities against androgen-independent prostate cancer cell lines as well as five additional types of human tumor cell lines. The most potent chalcone 5 showed superior antitumor activity in vivo with both oral and intraperitoneal administration at 3 mg/kg. Cell-based mechanism of action studies demonstrated that 5 induced cell accumulation at sub-G1 and G2/M phases without interfering with microtubule polymerization. Furthermore, several cancer cell growth-related proteins were identified by using chalcone 5 as a bait for the affinity purification of binding proteins. Full article
(This article belongs to the Special Issue Antitumor and Antiviral Potentials of Natural Products and Their Synthetic Analogs)
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13 pages, 2875 KiB  
Article
Smilax glabra Roxb. Inhibits Collagen Induced Adhesion and Migration of PC3 and LNCaP Prostate Cancer Cells through the Inhibition of Beta 1 Integrin Expression
by Oh Yun Kwon, Sujin Ryu, Jong Kyu Choi and Seung Ho Lee
Molecules 2020, 25(13), 3006; https://doi.org/10.3390/molecules25133006 - 30 Jun 2020
Cited by 12 | Viewed by 2847
Abstract
Smilax glabra Roxb. (SGR) has been used as a traditional medicine for brucellosis and syphilis. In this study, we investigated whether nontoxicological levels of water extract of SGR (WESGR) are effective for suppressing steps in the progression of prostate cancer, such as collagen-mediated [...] Read more.
Smilax glabra Roxb. (SGR) has been used as a traditional medicine for brucellosis and syphilis. In this study, we investigated whether nontoxicological levels of water extract of SGR (WESGR) are effective for suppressing steps in the progression of prostate cancer, such as collagen-mediated migration and adhesion and identified the target molecule responsible for such effects. We found that nontoxicological levels of WESGR did not attenuate PC3 and LNCaP cell adhesion to serum but did significantly do so with collagen. In addition, using the Boyden chamber assay, we found that nontoxicological levels of WESGR did not inhibit the migration of PC3 and LNCaP cells to a serum-coated area but did significantly attenuate migration to a collagen-coated area. Interestingly, the expression of α2β1 integrin, a known receptor of collagen, was not affected by ectopic administration of WESGR. However, WESGR significantly attenuated the expression of β1 integrin, but not α2 integrin when PC3 and LNCaP cells were placed on a collagen-coated plate, resulting in attenuation of focal adherent kinase phosphorylation. Finally, 5-O-caffeoylquinic acid was determined as a functional single component which is responsible for antiprostate cancer effects of WESGR. Taken together, our results suggest a novel molecular mechanism for WESGR-mediated antiprostate cancer effects at particular steps such as with migration and adhesion to collagen, and it could provide the possibility of therapeutic use of WESGR against prostate cancer progression. Full article
(This article belongs to the Special Issue Antitumor and Antiviral Potentials of Natural Products and Their Synthetic Analogs)
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