Natural Products as Anti-aging and Antidiabetic Agents

Dear Colleagues,

Aging is considered an inevitable multifactorial biological process that implicates genomic instability with altered cellular homeostasis and leads to a number of diseases. Although diverse biochemical and molecular pathways are implicated in this process, oxidative stress (OS) and inflammation are the hallmarks of aging. The uncontrolled production of free radical molecules affects the main cellular biomolecules such as lipids, proteins, and nucleic acids, and subsequently accelerates aging, including the onset and the progression of age-related diseases such as diabetes and cardiovascular disease. Thus, OS and inflammation have become major therapeutic targets to alleviate age-related complications. In fact, due to their robust antioxidant properties and minimal side effects, natural products have been increasingly explored with regard to their ameliorative effects against OS and inflammation to protect against cellular damages. Importantly, due to their increased consumption from diet and their potential development as nutraceuticals, research into naturally derived bioactive compounds has become essential to establish their therapeutic properties as anti-aging agents. Beyond their direct effects on aging, this Special Issue is open to contributions on the impact of natural products (toxicological and pharmacological aspects) on complications linked with aging, such as cancer, diabetes mellitus, and cardiovascular diseases, from preclinical models to clinical settings.

Dr. Ilenia Cirilli
Dr. Fabio Marcheggiani
Dr. Sonia Silvestri
Dr. Phiwayinkosi V. Dludla
Guest Editors

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