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Fluorinated Compounds: Access to Building Blocks and Their Transformation

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: 10 May 2024 | Viewed by 723

Special Issue Editor


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Guest Editor
1. CPE Lyon, Campus LyonTech-La Doua, 43 Bd du 11 Novembre 1918, 69616 Villeurbanne, France
2. Institute of Chemistry and Biochemistry (ICBMS–UMR CNRS 5246), University Lyon, CNRS, Université Lyon 1, CPE Lyon, 1 rue Victor Grignard, 69622 Lyon, France
Interests: organic synthesis; fluorine chemistry; organocatalysis; organometallic catalysis; cascade reactions; heteroelements chemistry; electrolytes for batteries

Special Issue Information

Dear Colleagues,

Organofluorinated compounds represent a major class of organic compounds as molecules bearing fluorinated moieties exhibit unique properties. As a result, such fluorinated products have become essential in a wide range of applications, from life sciences (pharmaceuticals and agrochemicals) to materials. In this context, there is a need to design new efficient synthetic routes to prepare organofluorinated compounds, or to design and synthesize new structures to achieve desired properties relating to the considered field.

This Special Issue in Molecules thus aims to highlight recent developments centered around access to fluorinated building blocks via the incorporation or transformation of fluorinated moieties into molecules, as well as the transformation of fluorinated molecules into more sophisticated scaffolds. We hope that the contributions in this Special Issue will provide useful data to the scientific community.

We thus kindly invite you to submit papers, original research articles, or reviews to this Special Issue of Molecules, titled “Fluorinated Compounds: Access to Building Blocks and their Transformation”.

Dr. Fabien Toulgoat
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • fluorine chemistry
  • organic synthesis
  • building blocks
  • organofluorinated compounds
  • new synthetic methods
  • medicinal chemistry
  • materials

Published Papers (1 paper)

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Research

16 pages, 1710 KiB  
Article
Copper-Catalyzed Synthesis of 4-CF3-1,2,3-Triazoles: An Efficient and Facile Approach via Click Reaction
by Tinghong Tang, Cuiting Chen, Xin Fu, Huilan Xu, Luyong Wu and Wenhao Chen
Molecules 2024, 29(6), 1191; https://doi.org/10.3390/molecules29061191 - 07 Mar 2024
Viewed by 546
Abstract
Incorporation of a trifluoromethyl group with 1,2,3-triazoles motifs was described. We explored a click reaction approach for regioselective synthesis of 1-susbstituted-4-trifluoromethyl-1,2,3-triazoles in which 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) reacts with commercial 2-bromo-3,3,3-trifluoropropene (BTP) to form 3,3,3-trifloropropyne (TFP) in situ. Arising from merits associated with the availability [...] Read more.
Incorporation of a trifluoromethyl group with 1,2,3-triazoles motifs was described. We explored a click reaction approach for regioselective synthesis of 1-susbstituted-4-trifluoromethyl-1,2,3-triazoles in which 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) reacts with commercial 2-bromo-3,3,3-trifluoropropene (BTP) to form 3,3,3-trifloropropyne (TFP) in situ. Arising from merits associated with the availability and stability of BTP, and the high efficiencies of CuI/1,10-Phenanthroline (Phen)-catalyzed cycloaddition reactions of azides with alkynes, this readily performed click process takes place to form the target 1,2,3-triazoles in high yields, and with a wide azide substrate scope. The potential value of this protocol was demonstrated by its application to a gram-scale reaction. Full article
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